用于心脏再生的干细胞疗法:过去、现在和未来。

IF 1.7 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Jaideep Kaur Gill, Sargun Kaur Rehsia, Elika Verma, Niketa Sareen, Sanjiv Dhingra
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引用次数: 0

摘要

心脏疾病仍然是全球死亡的主要原因。目前的临床策略,包括药物治疗、外科手术干预和器官移植,在不能使受损心肌再生的情况下,给患者带来的益处有限。在过去十年中,干细胞疗法因其独特的自我更新和免疫特权特性而引起了人们的浓厚兴趣。此外,干细胞能够分化成专门的细胞类型,使其成为治疗各种疾病的常用工具。本综述概述了不同类型干细胞对心血管疾病的治疗潜力。此外,它还阐明了每种细胞类型的优势和局限性。报告还深入分析了干细胞研究面临的挑战、临床转化的障碍及其可能的解决方案。它探讨了围绕胚胎干细胞的争议和替代方法的出现,如将诱导多能干细胞用于心脏治疗。总之,这篇综述为再生医学领域的研究人员、临床医生和决策者提供了宝贵的资源,指导开发安全有效的干细胞疗法,彻底改变患者护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Stem cell therapy for cardiac regeneration: past, present, and future.

Cardiac disorders remain the leading cause of mortality worldwide. Current clinical strategies, including drug therapy, surgical interventions, and organ transplantation offer limited benefits to patients without regenerating the damaged myocardium. Over the past decade, stem cell therapy has generated a keen interest owing to its unique self-renewal and immune privileged characteristics. Furthermore, the ability of stem cells to differentiate into specialized cell types, has made them a popular therapeutic tool against various diseases. This comprehensive review provides an overview of therapeutic potential of different types of stem cells in reference to cardiovascular diseases. Furthermore, it sheds light on the advantages and limitations associated with each cell type. An in-depth analysis of the challenges associated with stem cell research and the hurdles for its clinical translation and their possible solutions have also been elaborated upon. It examines the controversies surrounding embryonic stem cells and the emergence of alternative approaches, such as the use of induced pluripotent stem cells for cardiac therapeutic applications. Overall, this review serves as a valuable resource for researchers, clinicians, and policymakers involved in the field of regenerative medicine, guiding the development of safe and effective stem cell-based therapies to revolutionize patient care.

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来源期刊
CiteScore
4.00
自引率
4.80%
发文量
90
审稿时长
3-8 weeks
期刊介绍: Published since 1929, the Canadian Journal of Physiology and Pharmacology is a monthly journal that reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership. The journal periodically publishes a “Made In Canada” special section that features invited review articles from internationally recognized scientists who have received some of their training in Canada.
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