细胞外囊泡--牙周病与糖尿病并发症之间的潜在联系。

IF 2.8 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Molecular Oral Microbiology Pub Date : 2024-08-01 Epub Date: 2024-01-16 DOI:10.1111/omi.12449

Shengyuan Huang, Jiang Lin, Xiaozhe Han

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引用次数: 0

摘要

长期以来，人们一直认为牙周炎与糖尿病之间存在双向影响。牙周炎可能会影响糖尿病的血糖控制、胰岛素抵抗和糖尿病并发症。糖尿病会延缓伤口愈合，增加感染机会，从而加重牙周炎。细胞外囊泡（EVs）是真核细胞和原核细胞分泌的膜封闭球形结构的异质颗粒，在多种疾病中起着关键作用。本综述将从微生物和宿主细胞的角度介绍 EVs 的生物发生、释放和生物功能，讨论 EVs 在牙周炎和糖尿病发病过程中的功能特性，并探讨 EVs 在这两种疾病的发病机制和临床应用中的作用。此外，还讨论了它们的临床意义和诊断价值。

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Extracellular vesicles-Potential link between periodontal disease and diabetic complications.

It has long been suggested that a bidirectional impact exists between periodontitis and diabetes. Periodontitis may affect diabetes glycemic control, insulin resistance, and diabetic complications. Diabetes can worsen periodontitis by delaying wound healing and increasing the chance of infection. Extracellular vesicles (EVs) are heterogeneous particles of membrane-enclosed spherical structure secreted by eukaryotes and prokaryotes and play a key role in a variety of diseases. This review will introduce the biogenesis, release, and biological function of EVs from a microbial and host cell perspective, discuss the functional properties of EVs in the development of periodontitis and diabetes, and explore their role in the pathogenesis and clinical application of these two diseases. Their clinical implication and diagnostic value are also discussed.

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来源期刊

Molecular Oral Microbiology DENTISTRY, ORAL SURGERY & MEDICINE-MICROBIOLOGY

CiteScore

6.50

自引率

5.40%

发文量

审稿时长

>12 weeks

期刊介绍： Molecular Oral Microbiology publishes high quality research papers and reviews on fundamental or applied molecular studies of microorganisms of the oral cavity and respiratory tract, host-microbe interactions, cellular microbiology, molecular ecology, and immunological studies of oral and respiratory tract infections. Papers describing work in virology, or in immunology unrelated to microbial colonization or infection, will not be acceptable. Studies of the prevalence of organisms or of antimicrobials agents also are not within the scope of the journal. The journal does not publish Short Communications or Letters to the Editor. Molecular Oral Microbiology is published bimonthly.