{"title":"在评估溃疡性结肠炎 (UC) 活动性时比较粪便钙促蛋白与不同内窥镜评分及其在区分 IBS 和 IBD 方面的实用性","authors":"Kalpana Acharya, Vaishali Bhardwaj, Imran Chuahan, Syed Mushfiq, Sunil Bhatt, Brij Mohan Lamba","doi":"10.5005/jp-journals-10018-1411","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Ulcerative colitis (UC), a chronic inflammatory disease of gastrointestinal tract, can have initial presentation which is clinically difficult to differentiate from functional bowel disorders [irritable bowel syndrome (IBS) and irritable bowel disease (IBD)]. Conventional laboratory tests, such as erythrocyte sedimentation rate (ESR), C-reactive protein, and albumin express systemic patient responses instead of intestinal inflammation. In the last decade, fecal calprotectin, a calcium-binding protein, has been suggested as a sensitive marker of intestinal inflammation. However, only few studies have investigated its role in relation with the extent of the disease.</p><p><strong>Aim: </strong>To evaluate the usefulness of fecal calprotectin as a biomarker for disease activity in UC, its correlation with disease extent and its utility in differentiating IBS from IBD.</p><p><strong>Methods: </strong>A total of 75 patients (50 cases with colonoscopic evidence of inflammation and 25 cases with normal colonoscopic examination) were included in the study. Fecal calprotectin test was done on the day of colonoscopy. Severity of the disease was assessed by modified Mayo's endoscopy score (MMES).</p><p><strong>Results: </strong>Age and baseline parameters were comparable in both the groups (UC and IBS). Patients in the ulcerative group had tachycardia (95 vs 74), high ESR (26 vs 20), high leukocytes count (9198 vs 8852), high fecal calprotectin (594 vs 29), low albumin (3.00 vs 3.80) and low hemoglobin (11 vs 13.40). Minimum and maximum MMES were 2 and 13.2. A significant correlation was observed between fecal calprotectin and MMES (<i>p</i>-value < 0.001).</p><p><strong>Conclusion: </strong>Fecal calprotectin is a simple, noninvasive, cost-effective marker that is strongly associated with colorectal inflammation; moreover, it has better role in the differentiation of IBD (UC) from IBS.</p><p><strong>How to cite this article: </strong>Acharya K, Bhardwaj V, Chuahan I, <i>et al</i>. Comparison of Fecal Calprotectin with Different Endoscopic Scores in the Assessment of Ulcerative Colitis (UC) Activity and Its Utility in Differentiating IBS from IBD. Euroasian J Hepato-Gastroenterol 2023;13(2):120-123.</p>","PeriodicalId":516317,"journal":{"name":"Euroasian journal of hepato-gastroenterology","volume":"13 2","pages":"120-123"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10785125/pdf/","citationCount":"0","resultStr":"{\"title\":\"Comparison of Fecal Calprotectin with Different Endoscopic Scores in the Assessment of Ulcerative Colitis (UC) Activity and Its Utility in Differentiating IBS from IBD.\",\"authors\":\"Kalpana Acharya, Vaishali Bhardwaj, Imran Chuahan, Syed Mushfiq, Sunil Bhatt, Brij Mohan Lamba\",\"doi\":\"10.5005/jp-journals-10018-1411\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Ulcerative colitis (UC), a chronic inflammatory disease of gastrointestinal tract, can have initial presentation which is clinically difficult to differentiate from functional bowel disorders [irritable bowel syndrome (IBS) and irritable bowel disease (IBD)]. Conventional laboratory tests, such as erythrocyte sedimentation rate (ESR), C-reactive protein, and albumin express systemic patient responses instead of intestinal inflammation. In the last decade, fecal calprotectin, a calcium-binding protein, has been suggested as a sensitive marker of intestinal inflammation. However, only few studies have investigated its role in relation with the extent of the disease.</p><p><strong>Aim: </strong>To evaluate the usefulness of fecal calprotectin as a biomarker for disease activity in UC, its correlation with disease extent and its utility in differentiating IBS from IBD.</p><p><strong>Methods: </strong>A total of 75 patients (50 cases with colonoscopic evidence of inflammation and 25 cases with normal colonoscopic examination) were included in the study. Fecal calprotectin test was done on the day of colonoscopy. Severity of the disease was assessed by modified Mayo's endoscopy score (MMES).</p><p><strong>Results: </strong>Age and baseline parameters were comparable in both the groups (UC and IBS). Patients in the ulcerative group had tachycardia (95 vs 74), high ESR (26 vs 20), high leukocytes count (9198 vs 8852), high fecal calprotectin (594 vs 29), low albumin (3.00 vs 3.80) and low hemoglobin (11 vs 13.40). Minimum and maximum MMES were 2 and 13.2. A significant correlation was observed between fecal calprotectin and MMES (<i>p</i>-value < 0.001).</p><p><strong>Conclusion: </strong>Fecal calprotectin is a simple, noninvasive, cost-effective marker that is strongly associated with colorectal inflammation; moreover, it has better role in the differentiation of IBD (UC) from IBS.</p><p><strong>How to cite this article: </strong>Acharya K, Bhardwaj V, Chuahan I, <i>et al</i>. Comparison of Fecal Calprotectin with Different Endoscopic Scores in the Assessment of Ulcerative Colitis (UC) Activity and Its Utility in Differentiating IBS from IBD. 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引用次数: 0
摘要
背景：溃疡性结肠炎（UC）是一种胃肠道慢性炎症性疾病，其初期表现在临床上很难与功能性肠病[肠易激综合征（IBS）和肠易激综合征（IBD）]区分开来。传统的实验室检查，如红细胞沉降率（ESR）、C 反应蛋白和白蛋白，反映的是病人的全身反应，而不是肠道炎症。近十年来，粪便钙蛋白（一种钙结合蛋白）被认为是肠道炎症的敏感标记物。目的：评估粪便钙蛋白作为 UC 疾病活动性生物标志物的作用、其与疾病程度的相关性及其在区分 IBS 和 IBD 方面的实用性：研究共纳入 75 例患者（50 例有结肠镜炎症证据，25 例结肠镜检查正常）。在结肠镜检查当天进行粪便钙蛋白检测。疾病严重程度通过改良梅奥内镜检查评分（MMES）进行评估：结果：两组（溃疡性结肠炎和肠易激综合征）患者的年龄和基线参数相当。溃疡组患者心动过速（95 vs 74）、血沉增快（26 vs 20）、白细胞计数增高（9198 vs 8852）、粪便钙蛋白增高（594 vs 29）、白蛋白低（3.00 vs 3.80）和血红蛋白低（11 vs 13.40）。最低和最高 MMES 分别为 2 和 13.2。粪便热保护蛋白与 MMES 之间存在明显相关性（P 值 < 0.001）：结论：粪便钙蛋白是一种简单、无创、经济有效的标记物，与结直肠炎症密切相关；此外，它在区分 IBD（UC）和 IBS 方面具有更好的作用：Acharya K, Bhardwaj V, Chuahan I, et al. 粪钙蛋白与不同内镜评分在评估溃疡性结肠炎（UC）活动中的比较及其在区分IBS与IBD中的作用。Euroasian J Hepato-Gastroenterol 2023;13(2):120-123.
Comparison of Fecal Calprotectin with Different Endoscopic Scores in the Assessment of Ulcerative Colitis (UC) Activity and Its Utility in Differentiating IBS from IBD.
Background: Ulcerative colitis (UC), a chronic inflammatory disease of gastrointestinal tract, can have initial presentation which is clinically difficult to differentiate from functional bowel disorders [irritable bowel syndrome (IBS) and irritable bowel disease (IBD)]. Conventional laboratory tests, such as erythrocyte sedimentation rate (ESR), C-reactive protein, and albumin express systemic patient responses instead of intestinal inflammation. In the last decade, fecal calprotectin, a calcium-binding protein, has been suggested as a sensitive marker of intestinal inflammation. However, only few studies have investigated its role in relation with the extent of the disease.
Aim: To evaluate the usefulness of fecal calprotectin as a biomarker for disease activity in UC, its correlation with disease extent and its utility in differentiating IBS from IBD.
Methods: A total of 75 patients (50 cases with colonoscopic evidence of inflammation and 25 cases with normal colonoscopic examination) were included in the study. Fecal calprotectin test was done on the day of colonoscopy. Severity of the disease was assessed by modified Mayo's endoscopy score (MMES).
Results: Age and baseline parameters were comparable in both the groups (UC and IBS). Patients in the ulcerative group had tachycardia (95 vs 74), high ESR (26 vs 20), high leukocytes count (9198 vs 8852), high fecal calprotectin (594 vs 29), low albumin (3.00 vs 3.80) and low hemoglobin (11 vs 13.40). Minimum and maximum MMES were 2 and 13.2. A significant correlation was observed between fecal calprotectin and MMES (p-value < 0.001).
Conclusion: Fecal calprotectin is a simple, noninvasive, cost-effective marker that is strongly associated with colorectal inflammation; moreover, it has better role in the differentiation of IBD (UC) from IBS.
How to cite this article: Acharya K, Bhardwaj V, Chuahan I, et al. Comparison of Fecal Calprotectin with Different Endoscopic Scores in the Assessment of Ulcerative Colitis (UC) Activity and Its Utility in Differentiating IBS from IBD. Euroasian J Hepato-Gastroenterol 2023;13(2):120-123.
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