评估自体接种对育龄期生殖器传染性软疣疗效的临床研究。

Pub Date : 2023-07-01 Epub Date: 2023-12-06 DOI:10.4103/ijstd.ijstd_102_22
Durga Choudhary, Chinmai Yadav, Dilip Kachhawa, Deepti Rajoriya
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引用次数: 0

摘要

背景:传染性软疣(MC)通常表现为无症状或瘙痒、离散、光滑、肉色、圆顶状丘疹,中央有脐状突起。生殖器上的病变通常通过性传播,多见于青壮年。同种异体自体植入是一种简单的技术,有助于诱导细胞介导的抗原免疫反应,帮助清除局部和远处的病灶:研究旨在评估自体接种技术治疗生殖器 MC 在减少病变数量方面的疗效和副作用:31名生殖器软疣患者在皮肤科门诊就诊,其中30人仍在治疗。使用胰岛素注射器(30 G)从皮损邻近部位刺入界限清楚的软疣皮损。每两周评估一次结果,持续 2 个月:研究结束时,60%(n = 18)的患者反应极佳,20%(n = 6)的患者反应非常好,6.6%(n = 2)的患者反应良好,13.3%(n = 4)的患者反应较差:自体接种技术是一种有效的技术,能很好地清除 MC 病灶,减少复发机会和副作用,缩短远处病灶达到完全反应的时间。
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Clinical study to evaluate the efficacy of autoinoculation in genital molluscum contagiosum in reproductive age group.

Context: Molluscum contagiosum (MC) typically presents as asymptomatic or itchy, discrete, smooth, flesh-colored, dome-shaped papules with central umbilication. Lesions on the genitals are often sexually transmitted and tend to be seen in young adults. Homologous auto implantation is a simple technique which helps in inducing a cell-mediated immune response to the antigens, aiding clearance of both local and distant lesions.

Aim and objectives: The aim of the study is to evaluate the efficacy and side effect of the technique of autoinoculation for the treatment of genital MC in terms of reduction in number of lesions.

Materials and methods: Thirty-one patients having >5 genital molluscum attending skin outpatient department were enrolled out of which 30 remain. A well-defined mc lesion was approached using an insulin syringe (30 G) and pierced from a site just adjacent to the lesion. Results were assessed every 2 weeks for 2 months.

Results: 60% (n = 18) patients showed excellent response, 20% (n = 6) patients showed very good response, 6.6% (n = 2) patients showed good response and 13.3% (n = 4) showed poor response at the end of the study.

Conclusion: The autoinoculation technique is an effective technique in terms of excellent clearance of MC lesions with fewer chances of recurrence, side effects, and shorter duration taken to achieve a complete response to distant lesions.

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