miRNA-155 和 miRNA-499a 的低表达水平与 2 型糖尿病患者的肥胖有关。

IF 3 4区医学 Q2 GENETICS & HEREDITY

Epigenomics Pub Date : 2024-01-01 Epub Date: 2024-01-15 DOI:10.2217/epi-2023-0320

Andrea Latini, Giada De Benedittis, Cinzia Ciccacci, Giuseppe Novelli, Vincenza Spallone, Paola Borgiani

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引用次数: 0

摘要

背景与目的：本研究调查了之前观察到的与糖尿病多发性神经病变相关的三种循环 miRNA 与肥胖症之间可能存在的相关性。方法与结果对 49 名 2 型糖尿病患者的 miR-128a、miR-155 和 miR499a 的表达水平进行了评估。分析结果显示，肥胖受试者的 miR-155 和 miR-499a 表达水平明显下降。尤其是在中心性肥胖的 2 型糖尿病受试者中，这种降低似乎更为明显。结论研究结果表明，这些 miRNA 可能参与了肥胖驱动的致病机制。

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Low expression levels of miRNA-155 and miRNA-499a are associated with obesity in Type 2 diabetes.

Background & aims: This study investigated a possible correlation between three circulating miRNAs, previously observed to be associated to diabetic polyneuropathy, and the obesity condition. Methods & results: The expression levels of miR-128a, miR-155 and miR499a were evaluated in 49 participants with Type 2 diabetes, divided into different groups based on the presence or absence of obesity and central obesity. The analyses revealed a significant decrease of miR-155 and miR-499a expression levels in obese subjects. In particular, the reduction appears to be even more significant in Type 2 diabetes subjects with central obesity. Conclusion: The results suggest that these miRNAs could be involved in obesity-driven pathogenetic mechanisms.

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.