Luqiao Luo, Fei Qiao, Ke Zhou, Qiang Tu, Jiao He, Haoqi Huang, Chao Liu, Huihua Cai
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引用次数: 0
摘要
目的：研究宫颈癌患者潜在异常表观遗传修饰与免疫细胞浸润之间的关系。材料与方法：利用癌症基因组图谱数据库中的 RNA 表达谱，探讨关键生物标志物与肿瘤浸润免疫细胞之间的关系，并进行临床标本验证。结果：建立了两个提名图模型，一个是特定的 ceRNA，另一个是基于相关肿瘤浸润免疫细胞的生物标志物。此外，一个关键的生物标记物（RIPOR2）与 CD8 T 细胞显著相关。结论RIPOR2和CD8 T细胞在宫颈癌的发生和发展过程中起着至关重要的作用，这表明它们有可能成为指导未来治疗策略的标志物。
Constructed competitive endogenous RNA network and patterns of immune infiltration revealing the prognostic signature for cervical cancer.
Aim: To investigate the relationship between potential abnormal epigenetic modification and immune cell infiltration in patients with cervical carcinoma. Materials & methods: RNA expression profiles from The Cancer Genome Atlas database were used to explore the relationship between key biomarkers and tumor-infiltrating immune cells and for clinical specimen validation. Results: Two nomogram models were developed, one with specific ceRNA and the other based on biological markers of related tumor-infiltrating immune cells. Moreover, a key biomarker (RIPOR2), which was significantly relevant to CD8 T cells. Conclusion: RIPOR2 and CD8 T cells play a crucial role in the development and progression of cervical carcinoma, suggesting their potential as markers for guiding future therapeutic strategies.
期刊介绍：
Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community.
Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
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