金黄色葡萄球菌的生物膜蛋白质组及其对生物膜相关感染治疗干预的影响。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Dileep Francis, Gopika Veeramanickathadathil Hari, Abhijith Koonthanmala Subash, Anusha Bhairaddy, Atheene Joy
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引用次数: 0

摘要

由于金黄色葡萄球菌能够造成危及生命的感染,并以惊人的速度产生抗生素耐药性,因此是医疗保健领域的一个主要问题。它经常与医院获得性感染有关,尤其是与设备相关的感染。金黄色葡萄球菌引起的全身感染很难治疗,死亡率和发病率都很高。金黄色葡萄球菌能够形成称为生物膜的社会联合体,这使得情况更加恶化。生物膜将具有相互沟通能力的细胞群落嵌入多糖或蛋白质基质中,并共享资源。金黄色葡萄球菌会在组织和有条件的非生物表面形成生物膜。生物膜对抗生素有很强的耐受性,有助于逃避宿主的免疫反应。生物膜会加剧设备相关感染的严重性和顽固性。生物膜的形成涉及多种生物大分子,如多糖、蛋白质和核酸,它们在结构上和功能上发挥着不同的作用。相互关联的信号通路和调控分子调节着这些分子的表达。全面了解生物膜形成的分子生物学原理有助于设计有效的抗生物膜疗法。虽然杀菌剂、抗菌肽、噬菌体和纳米结合的抗生物膜剂已被采用,并取得了不同程度的成功,但仍然需要有效的、临床上可行的抗生物膜疗法。在生物膜形成过程中表达和利用的蛋白质构成生物膜蛋白质组,是抗生物膜策略的一个特别有吸引力的目标。可以通过探索蛋白质组来确定潜在的抗生物膜药物靶点,并用于合理的药物研发。为了揭示生物膜蛋白质组,本章探讨了生物膜的形成机制及其调控。此外,本章还探讨了针对生物膜蛋白质组的抗生物膜疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The biofilm proteome of Staphylococcus aureus and its implications for therapeutic interventions to biofilm-associated infections.

Staphylococcus aureus is a major healthcare concern due to its ability to inflict life-threatening infections and evolve antibiotic resistance at an alarming pace. It is frequently associated with hospital-acquired infections, especially device-associated infections. Systemic infections due to S. aureus are difficult to treat and are associated with significant mortality and morbidity. The situation is worsened by the ability of S. aureus to form social associations called biofilms. Biofilms embed a community of cells with the ability to communicate with each other and share resources within a polysaccharide or protein matrix. S. aureus establish biofilms on tissues and conditioned abiotic surfaces. Biofilms are hyper-tolerant to antibiotics and help evade host immune responses. Biofilms exacerbate the severity and recalcitrance of device-associated infections. The development of a biofilm involves various biomolecules, such as polysaccharides, proteins and nucleic acids, contributing to different structural and functional roles. Interconnected signaling pathways and regulatory molecules modulate the expression of these molecules. A comprehensive understanding of the molecular biology of biofilm development would help to devise effective anti-biofilm therapeutics. Although bactericidal agents, antimicrobial peptides, bacteriophages and nano-conjugated anti-biofilm agents have been employed with varying levels of success, there is still a requirement for effective and clinically viable anti-biofilm therapeutics. Proteins that are expressed and utilized during biofilm formation, constituting the biofilm proteome, are a particularly attractive target for anti-biofilm strategies. The proteome can be explored to identify potential anti-biofilm drug targets and utilized for rational drug discovery. With the aim of uncovering the biofilm proteome, this chapter explores the mechanism of biofilm formation and its regulation. Furthermore, it explores the antibiofilm therapeutics targeted against the biofilm proteome.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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