蛋白质组学和基因组学对恶性骨肉瘤的启示。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Nachammai Kathiresan, Chandrabose Selvaraj, Sangavi Pandian, Gowtham Kumar Subbaraj, Abdulaziz S Alothaim, Sher Zaman Safi, Langeswaran Kulathaivel
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引用次数: 0

摘要

骨肉瘤是一种恶性骨肿瘤。骨肉瘤是一种原发性骨恶性肿瘤,能够产生类骨组织或未成熟骨。原发性骨病变随后发生恶性变性的情况在成人中较少发生。热休克蛋白、Cofilin、Annexins、胰岛素样生长因子、转化生长因子-β、受体酪氨酸激酶、Ezrin、Runx2、SATB2、ATF4、Annexins、cofilin、表皮生长因子受体、血管内皮生长因子、视网膜母细胞瘤 1(Rb1)和分泌蛋白等多种蛋白质的过度表达与骨肉瘤的发生和发展有关。这些蛋白参与细胞粘附、迁移、侵袭以及细胞周期和凋亡的控制。在基因组研究中,骨肉瘤与多种基因异常有关,包括染色体重排、基因突变和基因扩增。这些不同表达的蛋白质可用作早期识别生物标志物或治疗目标。蛋白质组学和基因组学在提高我们对骨肉瘤的分子认识方面发挥着重要作用,它们的结合为我们深入了解这种侵袭性骨癌提供了重要依据。本综述将讨论有助于我们更好地了解骨肉瘤病因的肿瘤生物学,以及如何利用它们找到新的治疗靶点并提高骨肉瘤患者的生存率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Proteomics and genomics insights on malignant osteosarcoma.

Osteosarcoma is a malignant osseous neoplasm. Osteosarcoma is a primary bone malignancy capable of producing osteoid tissue or immature bones. A subsequent malignant degeneration of the primary bone pathology occurs less frequently in adults. The over-expression of several proteins, including Heat shock proteins, Cofilin, Annexins, Insulin-like growth factor, transforming growth factor-β, Receptor tyrosine kinase, Ezrin, Runx2, SATB2, ATF4, Annexins, cofilin, EGFR, VEGF, retinoblastoma 1 (Rb1) and secreted protein, has been associated to the development and progression of osteosarcoma. These proteins are involved in cell adhesion, migration, invasion, and the control of cell cycle and apoptosis. In genomic studies, osteosarcoma has been associated with several genetic abnormalities, including chromosomal rearrangements, gene mutations, and gene amplifications. These differentially expressed proteins could be used as early identification biomarkers or treatment targets. Proteomics and genomics play significant parts in enhancing our molecular understanding of osteosarcoma, and their integration provides essential insights into this aggressive bone cancer. This review will discuss the tumour biology that has assisted in helping us better understand the causes of osteosarcoma and how they could potentially be used to find new treatment targets and enhance the survival rate for osteosarcoma patients.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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