{"title":"基于(硫代)巴比妥酸及其类似物的嘧啶并[5,4-c]喹啉的合成、反应和生物活性(第四部分)","authors":"Ameen Abu-Hashem, Taha Ameen, Emad El-Telbani, Hoda A.R. Hussein, Moustafa Gouda","doi":"10.2174/0118756298276728231130042823","DOIUrl":null,"url":null,"abstract":": Pyrimido [5, 4-c] quinolone derivatives are significant synthetic targets that show numerous interesting biological activities. The pyrimido [4, 5-b] quinoline is the most famous source of these derivatives, which has been used in medicine to antitumor and target different diseases. Since the segregation of quinoline derivatives, many synthetic methodologies were advanced for their synthesis. Despite the current interesting findings on this class of pyrimidoquinoline, the chemical literature deficits a comprehensive summary of the synthetic methodologies and biological activities of pyrimido [5, 4-c] quinoline derivatives. This review focuses on recent advances in pyrimido [5, 4-c] quinolines chemistry via debating diverse synthetic ways developed for the preparation of pyrimido [5, 4-c] quinolines and other unique derivatives that exhibited promising biological activities. Also, it sheds light on the most widespread reactions of pyrimidoquinolines and the employment of these derivatives as the essential building blocks for different biologically active compounds:. Among these reactions used to prepare pyrimido [5, 4-c] quinoline derivatives are the following: Biginelli-type one or three-component reaction, Micheal addition, intermolecular cyclization, cyclo-condensation, acylation, Vielsmeir formylation, Suzuki cross-coupling reaction, transformation, oxidation-reduction, esterification, dehydration, decarboxylation, methylation, chlorination, alkylation.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis, Reactions and Biological Activity of Pyrimido [5, 4-c] Quinolines based on (Thio)Barbituric Acid and their Analogous (Part IV)\",\"authors\":\"Ameen Abu-Hashem, Taha Ameen, Emad El-Telbani, Hoda A.R. Hussein, Moustafa Gouda\",\"doi\":\"10.2174/0118756298276728231130042823\",\"DOIUrl\":null,\"url\":null,\"abstract\":\": Pyrimido [5, 4-c] quinolone derivatives are significant synthetic targets that show numerous interesting biological activities. The pyrimido [4, 5-b] quinoline is the most famous source of these derivatives, which has been used in medicine to antitumor and target different diseases. Since the segregation of quinoline derivatives, many synthetic methodologies were advanced for their synthesis. Despite the current interesting findings on this class of pyrimidoquinoline, the chemical literature deficits a comprehensive summary of the synthetic methodologies and biological activities of pyrimido [5, 4-c] quinoline derivatives. This review focuses on recent advances in pyrimido [5, 4-c] quinolines chemistry via debating diverse synthetic ways developed for the preparation of pyrimido [5, 4-c] quinolines and other unique derivatives that exhibited promising biological activities. Also, it sheds light on the most widespread reactions of pyrimidoquinolines and the employment of these derivatives as the essential building blocks for different biologically active compounds:. Among these reactions used to prepare pyrimido [5, 4-c] quinoline derivatives are the following: Biginelli-type one or three-component reaction, Micheal addition, intermolecular cyclization, cyclo-condensation, acylation, Vielsmeir formylation, Suzuki cross-coupling reaction, transformation, oxidation-reduction, esterification, dehydration, decarboxylation, methylation, chlorination, alkylation.\",\"PeriodicalId\":18632,\"journal\":{\"name\":\"Mini-reviews in Organic Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-01-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mini-reviews in Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.2174/0118756298276728231130042823\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mini-reviews in Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/0118756298276728231130042823","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Synthesis, Reactions and Biological Activity of Pyrimido [5, 4-c] Quinolines based on (Thio)Barbituric Acid and their Analogous (Part IV)
: Pyrimido [5, 4-c] quinolone derivatives are significant synthetic targets that show numerous interesting biological activities. The pyrimido [4, 5-b] quinoline is the most famous source of these derivatives, which has been used in medicine to antitumor and target different diseases. Since the segregation of quinoline derivatives, many synthetic methodologies were advanced for their synthesis. Despite the current interesting findings on this class of pyrimidoquinoline, the chemical literature deficits a comprehensive summary of the synthetic methodologies and biological activities of pyrimido [5, 4-c] quinoline derivatives. This review focuses on recent advances in pyrimido [5, 4-c] quinolines chemistry via debating diverse synthetic ways developed for the preparation of pyrimido [5, 4-c] quinolines and other unique derivatives that exhibited promising biological activities. Also, it sheds light on the most widespread reactions of pyrimidoquinolines and the employment of these derivatives as the essential building blocks for different biologically active compounds:. Among these reactions used to prepare pyrimido [5, 4-c] quinoline derivatives are the following: Biginelli-type one or three-component reaction, Micheal addition, intermolecular cyclization, cyclo-condensation, acylation, Vielsmeir formylation, Suzuki cross-coupling reaction, transformation, oxidation-reduction, esterification, dehydration, decarboxylation, methylation, chlorination, alkylation.
期刊介绍:
Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges.
The journal encourages submission of reviews on emerging fields of organic chemistry including:
Bioorganic Chemistry
Carbohydrate Chemistry
Chemical Biology
Chemical Process Research
Computational Organic Chemistry
Development of Synthetic Methodologies
Functional Organic Materials
Heterocyclic Chemistry
Macromolecular Chemistry
Natural Products Isolation And Synthesis
New Synthetic Methodology
Organic Reactions
Organocatalysis
Organometallic Chemistry
Theoretical Organic Chemistry
Polymer Chemistry
Stereochemistry
Structural Investigations
Supramolecular Chemistry