Quercetin Supplementation has no Synergetic Effect with High-Intensity Interval Training in Ameliorate Lipid Profile in Male Diabetic Rats

Background: In diabetic patients, lipid profile (LP) management is crucial. Quercetin (QUE), as an antioxidant supplement, has received a great deal of attention in improving the LP. Objectives: The current study aimed to investigate the simultaneous effect of high-intensity interval training (HIIT) and QUE on LP in male diabetic rats. Methods: Fifty Wistar male rats were randomly assigned to healthy control (HC; n = 10), diabetic control (DC; n = 10), high-intensity interval training (HIIT; n = 10), quercetin supplement (QS; n = 10), high-intensity interval training and quercetin (HIIQ; n = 10). QUE was given (20 mg/kg/d) to the animals daily for six weeks. HIIT has performed five sessions per week for six weeks in 8-10 sets with 85 - 65% of the maximum oxygen consumption (VO2max) on the treadmill. Blood samples were taken directly from the animal’s heart 48 hours after the last training session, and high-density lipoprotein (HDL-C), low-density lipoproteins (LDL-C), triglycerides (TG) cholesterol (CHOL), and fasting blood glucose (FBS) were measured in the serum. To analyze the data, two-way analysis of variance (ANOVA) and Tukey's post hoc test were used. Results: There was no significant difference between HIIQ with HIIT, QS in LDH-C and LDL-C (P > 0.05). Also, no significant difference was seen between HIIT, QS, and HIIQ in TG concentration after intervention (P > 0.05). CHOL was significantly lower in HIIT than QS (P = 0.001), while there was no significant difference between the HIIQ with QS (P > 0.05). Also, there was no significant difference between QS and HIIQ in FBS (P > 0.05). Conclusions: It seems that high-intensity interval training and quercetin alone can be effective in improving lipid profile. However, quercetin does not have a synergetic effect with high-intensity interval training in ameliorating lipid profile in diabetic male rats.