高级糖化终产物与 1 型糖尿病患者和非 1 型糖尿病患者的骨矿物质密度、骨小梁评分和骨转换标志物无关:一项横断面研究

IF 3.4 Q2 ENDOCRINOLOGY & METABOLISM
JBMR Plus Pub Date : 2024-01-04 DOI:10.1093/jbmrpl/ziad018
J. Coll, Anne-Frédérique Turcotte, William D Leslie, Laëtitia Michou, S. J. Weisnagel, Fabrice Mac-Way, Caroline Albert, Claudie Berger, Suzanne N Morin, Rémi Rabasa-Lhoret, Claudia Gagnon
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引用次数: 0

摘要

目前还不清楚高级糖化终产物(AGEs)是否与 1 型糖尿病(T1D)的骨脆性有关。我们评估了通过皮肤自发荧光检测的皮肤 AGEs 和血清 AGEs(喷托苷、羧甲基赖氨酸 [CML])是否与通过 DXA 检测的 BMD(腰椎、髋关节、桡骨远端)、骨小梁评分 (TBS)、血清骨转换标志物(BTMs:在患有和未患有 T1D 的参与者中,采用线性回归模型研究了骨密度测量(腰椎、髋关节、桡骨远端)、骨小梁评分(TBS)、血清骨转换标志物(BTMs:1 型胶原 C 端交叉连接端肽 CTX;1 型胶原 N 端前肽 P1NP;骨钙素)和硬骨素。使用线性回归模型和交互项来检验 T1D 状态对效应的影响。在患有 T1D 的参与者中,使用 Spearman 相关性评估了皮肤和血清 AGEs 之间以及 AGEs 和 3 年 HbA1C 之间的相关性。数据为平均值±SD或中位数(四分位数间距)。我们纳入了参加横断面研究并进行了 BMD 和 TBS 评估的人(106 名 T1D 患者/65 名对照组患者,53.2% 为女性,年龄为 43±15 岁,BMI 为 26.6±5.5 kg/m2)。T1D患者的糖尿病病程为27.6±12.3年,平均3年HbA1C为7.5±0.9%,皮肤AGE为2.15±0.54任意单位。65 名 T1D 患者/57 名对照组患者的子组进行了 BTMs 和硬骨素测量,T1D 患者还进行了血清戊糖苷(16.8[8.2-32.0] ng/mL)和 CML [48.0±16.8] ng/mL)测量。T1D患者与对照组相比,股骨颈BMD、TBS和BTM较低,而硬骨素水平相似。T1D状态不会改变AGEs与骨骼结果之间的关联。在调整混杂因素之前,皮肤AGEs与总髋关节和股骨颈BMD、TBS、BTMs和硬骨素有明显的相关性,但在调整混杂因素之后则没有明显的相关性。血清 AGE 与任何骨骼结果均无关联。皮肤和血清 AGEs 之间以及 AGEs 和 3 年 HbA1C 之间没有明显的相关性。总之,在控制相对较好的 T1D 患者和未患糖尿病的患者中,皮肤和血清 AGEs 与 BMD、TBS、BTMs 和硬骨素并无独立关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advanced Glycation End Products Are Not Associated With Bone Mineral Density, Trabecular Bone Score and Bone Turnover Markers in Adults With and Without Type 1 Diabetes: A Cross-Sectional Study
It is unclear if advanced glycation end products (AGEs) are involved in the bone fragility of type 1 diabetes (T1D). We evaluated whether skin AGEs by skin autofluorescence and serum AGEs (pentosidine, carboxymethyl-lysine [CML]) are independently associated with BMD by DXA (lumbar spine, hip, distal radius), trabecular bone score (TBS), serum bone turnover markers (BTMs: C-terminal crossed-linked telopeptide of type 1 collagen, CTX; procollagen type 1 N-terminal propeptide, P1NP; osteocalcin), and sclerostin in participants with and without T1D. Linear regression models were used, with interaction terms to test effect modification by T1D status. In participants with T1D, correlations between skin and serum AGEs as well as between AGEs and 3-year HbA1C were evaluated using Spearman’s correlations. Data are mean±SD or median(interquartile range). We included individuals who participated in a cross-sectional study and had BMD and TBS assessment (106 T1D/65 controls, 53.2% women, age 43±15 years, BMI 26.6±5.5 kg/m2). Participants with T1D had diabetes for 27.6±12.3 years, a mean 3-year HbA1C of 7.5±0.9% and skin AGEs of 2.15±0.54 arbitrary units. A subgroup of 65 T1D/57 controls had BTMs and sclerostin measurements, and those with T1D also had serum pentosidine (16.8[8.2-32.0] ng/mL) and CML [48.0±16.8] ng/mL) measured. Femoral neck BMD, TBS, and BTMs were lower while sclerostin levels were similar in participants with T1D vs controls. T1D status did not modify the associations between AGEs and bone outcomes. Skin AGEs were significantly associated with total hip and femoral neck BMD, TBS, BTMs, and sclerostin before, but not after adjustment for confounders. Serum AGEs were not associated with any bone outcome. There were no significant correlations between skin and serum AGEs, or between AGEs and 3-year HbA1C. In conclusion, skin and serum AGEs are not independently associated with BMD, TBS, BTMs, and sclerostin in participants with relatively well-controlled T1D and participants without diabetes.
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来源期刊
JBMR Plus
JBMR Plus Medicine-Orthopedics and Sports Medicine
CiteScore
5.80
自引率
2.60%
发文量
103
审稿时长
8 weeks
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