肿瘤临床试验中的 T 细胞免疫球蛋白和含粘蛋白域蛋白 3 (TIM-3) 抑制剂：综述

Q3 Medicine

Journal of Immunotherapy and Precision Oncology Pub Date : 2024-01-08 DOI:10.36401/jipo-23-4

Benjamin Duong, Pratyush Banskota, Gerald Falchook

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引用次数: 0

摘要

含 T 细胞免疫球蛋白和粘蛋白结构域的蛋白 3（TIM-3）是一种存在于多种免疫细胞上的受体，通常在癌症患者体内过度表达。由于其在免疫细胞中的选择性表达以及在临床前模型中的初步疗效，TIM-3 是一种很有希望的癌症治疗靶点。目前正在开发和研究单药治疗和联合治疗方案。本临床综述旨在总结和梳理过去、现在和未来临床试验中的 TIM-3 抑制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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T cell Immunoglobulin and Mucin Domain Containing Protein 3 (TIM-3) Inhibitors in Oncology Clinical Trials: A Review

T cell immunoglobulin and mucin domain containing protein 3 (TIM-3) is a receptor found on a multitude of immune cells and is commonly overexpressed in patients with cancer. Due to its selective expression in immune cells and its preliminary efficacy in preclinical models, TIM-3 is a promising target as a treatment for cancer. Both monotherapy and combination regimens are being developed and are currently under investigation. This clinical review seeks to summarize and compile past, present, and future TIM-3 inhibitors in clinical trials.

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来源期刊

Journal of Immunotherapy and Precision Oncology Medicine-Oncology

CiteScore

2.40

自引率

0.00%

发文量