联合检测 NSCLC 血浆 cfDNA 浓度和完整性的诊断价值

Pub Date : 2024-01-11 DOI:10.2217/lmt-2023-0009

Sai Ren, Chunli Yu, Qing Huang

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引用次数: 0

摘要

目的：评估血浆 cfDNA 浓度和完整性联合检测在 NSCLC 早期诊断中的价值。方法：采用实时荧光定量 PCR采用实时荧光定量 PCR 检测 71 名 NSCLC 患者和 53 名健康人血浆 cfDNA 的浓度和完整性。结果与单独检测血浆 cfDNA 浓度或单独检测血浆 cfDNA 完整性相比，联合检测血浆 cfDNA 浓度和血浆 cfDNA 完整性在区分 I/II 期 NSCLC 患者和健康人群方面具有更高的诊断能力。联合检测血浆 cfDNA 浓度和完整性的 AUC、灵敏度和特异性分别为 0.781、0.62 和 0.85。结论联合检测血浆 cfDNA 浓度和完整性可提高 NSCLC 检测的诊断价值。

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Diagnostic value of combined detection of plasma cfDNA concentration and integrity in NSCLC

Aim: To evaluate the value of combined detection of plasma cfDNA concentration and integrity in the early diagnosis of NSCLC. Methods: Real-time fluorescence quantitative PCR was used to determine the concentration and integrity of plasma cfDNA in 71 NSCLC patients and 53 healthy people. Results: Combined detection of plasma cfDNA concentration and integrity had higher diagnostic power in differentiating NSCLC patients with stage I/II from healthy people than detection of plasma cfDNA concentration alone or integrity alone. The AUC, sensitivity and specificity of the combined detection of plasma cfDNA concentration and integrity were 0.781, 0.62 and 0.85. Conclusion: Combined detection of plasma cfDNA concentration and integrity could improve the diagnostic value in NSCLC detection.

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