评估可能的阿尔茨海默氏症导致的神经认知障碍时的偶然负变异

IF 3.2 Q2 CLINICAL NEUROLOGY
A. Montoya-Pedrón, Carmen María Ocaña Montoya, J. E. Santos Toural, Tania Acosta Lee, M. Sánchez-Hechavarría, Erislandis López-Galán, G. Muñoz-Bustos
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引用次数: 0

摘要

或然负变异(CNV)作为可能由阿尔茨海默病引起的神经认知障碍的生物标志物,其有用性基于其可能的生理相关性。然而,CNV 在这些疾病诊断评估中的应用仍处于起步阶段。本研究的目的是通过记录一组可能患有阿尔茨海默病的神经认知障碍患者的潜在 CNV,描述他们在非特异性全局注意力领域的信息认知处理模式。我们对病例和对照组进行了实验研究。样本包括 39 名根据 DSM-5 被归类为可能患有阿尔茨海默病的神经认知障碍亚型患者,以及由 53 名认知功能正常的受试者组成的对照组。CNV 电位采用标准协议进行登记。方差分析显示,三个研究组的 CNV 总振幅的平均值和置信区间存在显著差异。晚期 CNV 节段振幅可以区分患者组中轻度和重度功能障碍的程度。通过 CNV 电位总振幅可以有效区分正常认知功能和可能由阿尔茨海默病引起的神经认知障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Contingent Negative Variation in the Evaluation of Neurocognitive Disorders Due to Possible Alzheimer’s Disease
The usefulness of Contingent Negative Variation (CNV) potential as a biomarker of neurocognitive disorders due to possible Alzheimer’s disease, is based on its possible physiological correlates. However, its application in the diagnostic evaluation of these disorders is still incipient. The aim of this study is to characterize the patterns of cognitive processing of information in the domain of nonspecific global attention, by recording potential CNV in a group of patients with neurocognitive disorders due to possible Alzheimer’s disease. An experimental study of cases and controls was carried out. The sample included 39 patients classified according to DSM-5 with a neurocognitive disorder subtype possibly due Alzheimer’s disease, and a Control Group of 53 subjects with normal cognitive functions. CNV potential was registered using standard protocol. The analysis of variance obtained significant differences in mean values and confidence intervals of total CNV amplitude between the three study groups. The late CNV segment amplitudes makes it possible to discriminate between the level of mild and major dysfunction in the group of patients. The CNV total amplitudes of potential allows for effective discrimination between normal cognitive functioning and neurocognitive disorders due to possible Alzheimer’s disease.
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来源期刊
Neurology International
Neurology International CLINICAL NEUROLOGY-
CiteScore
3.70
自引率
3.30%
发文量
69
审稿时长
11 weeks
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