非创伤性患者髌骨骨关节炎与膝关节人口学特征和解剖学变异之间的关系。

International journal of physiology, pathophysiology and pharmacology Pub Date : 2023-12-15 eCollection Date: 2023-01-01
Ghazaleh Jamalipour Soufi, Ali Hekmatnia, Farzaneh Hekmatnia, Andrew Parviz Zarei, Mahshid Bahrami, Sina Rasti, Farshad Riahi
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引用次数: 0

摘要

背景:髌骨骨关节炎(PFOA)是造成膝关节不适和损伤的常见原因,尤其是在运动员中。髌骨股骨关节炎的发生与膝关节解剖变异有关,如髌骨发育不良和髌骨上端。然而,人们对这些解剖变异与 PFOA 发病之间的关系仍然知之甚少。本研究旨在调查一组患者的 PFOA 与膝关节解剖变异之间的关系:研究包括 200 名 PFOA 患者和 200 名健康对照者。在这项研究中,我们调查了骨关节炎与解剖变异和人口特征的关系。参与者接受了膝关节磁共振成像(MRI)评估,并对解剖变异进行了评估,包括髌骨发育不良和髌骨突出。此外,还根据软骨面积和深度以及骨髓受累情况和骨质增生的存在情况对 PFOA 的严重程度进行了分级:结果:两组患者在胫骨结节-椎弓根沟(TT-TG)距离、髌骨位置、椎弓根发育不良和Insall-Salvati比值方面存在明显统计学差异。病例的平均胫骨结节-胫骨沟距离、髌骨位置和Insall-Salvati比率均明显高于对照组(结论:胫骨结节-胫骨沟距离、髌骨位置和Insall-Salvati比率均高于对照组):包括TT-TG距离、髌骨发育不良和Insall-Salvati比率在内的膝关节解剖变异是PFOA进展的重要风险因素。研究结果还表明,与人口统计学信息相比,较高的体重指数(BMI)和较大的年龄与更多的核磁共振成像骨关节炎膝关节评分(MOAKS)相关。在解剖变异中,较高的 TT-TG 距离和较高的套管发育不良等级与较多的 MOAKS 测量值有显著关系。了解这些因素之间的关系具有重要的临床和研究意义,有助于开发新的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between patellofemoral osteoarthritis with demographic features and anatomical variants of the knee in non-traumatic patients.

Background: Patellofemoral osteoarthritis (PFOA) is a common cause of knee discomfort and impairment, particularly among athletes. The development of PFOA has been associated with anatomical knee variations, such as trochlear dysplasia and patella alta. However, the relationship between these anatomical variants and the development of PFOA remains poorly understood. This study aimed to investigate the association between PFOA and knee anatomical variants in a cohort of patients.

Methods: The study included 200 patients with PFOA and 200 healthy controls. In this study, we investigate the relationship of osteoarthritis with both anatomical variants and demographic characteristics. The participants underwent Magnetic resonance imaging (MRI) evaluation of the knee, and anatomical variants including trochlear dysplasia and patella alta were assessed. The severity of PFOA was also graded based on cartilage area and depth, as well as the bone marrow involvement and presence of osteophytes.

Results: Statistically significant differences were observed between the two groups in terms of Tibial tuberosity-trochlear groove (TT-TG) distance, patella position, trochlear dysplasia, and Insall-Salvati ratio. The mean TT-TG distance, prevalence of alta patella position, and Insall-Salvati ratio were significantly higher in cases (P<0.001 for all), and cases had a higher incidence of trochlear dysplasia (P<0.001). There were no significant differences between cases and controls regarding patella baja.

Conclusion: Anatomical knee variants, including the TT-TG distance, trochlear dysplasia, and Insall-Salvati ratio, are significant risk factors for PFOA progression. The results also indicate that higher BMI and older age are significantly associated with more measures of MRI Osteoarthritis Knee Score (MOAKS) than demographic information. Among anatomical variants, a higher TT-TG distance and an increased grade of trochlear dysplasia show a significant relationship with more measures of MOAKS. Understanding the relationship between these factors has important clinical and research implications and can help inform the development of new treatments.

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