舌下免疫疗法对临床和实验室自身免疫的影响

IF 2.7 4区医学 Q3 IMMUNOLOGY

Immunotherapy Pub Date : 2024-03-01 Epub Date: 2024-01-12 DOI:10.2217/imt-2023-0231

Andrzej Bozek, Szymon Mućka, Martyna Miodonska, Anna Zlik, Magdalena Mroz-Dybowska

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引用次数: 0

摘要

背景：有关舌下免疫疗法（SLIT）长期安全性的数据仍然很少。本研究旨在评估舌下免疫疗法前后患者出现自身免疫性疾病的情况。材料与方法：监测自身免疫性疾病的新病例。将 SLIT 组患者（n = 816）与对照组（n = 1096）进行比较。结果与对照组相比，SLIT 组的自身免疫性疾病新发病率较低：18（2.2%）对 58（5.3%）；P 结论：SLIT 对自身免疫疾病的发病率没有显著影响：SLIT对诱发自身免疫性疾病没有明显影响。

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Effect of sublingual immunotherapy on clinical and laboratory autoimmunity.

Background: There still are few data on the long-term safety of sublingual immunotherapy (SLIT). The aim of this study was to assess the appearance of autoimmune diseases in patients before and after SLIT. Materials & methods: New cases of autoimmune diseases were monitored. Patients in the SLIT group (n = 816) were compared with controls (n = 1096). Results: The new incidences of autoimmune diseases in the SLIT group were lower compared with the control group: 18 (2.2%) versus 58 (5.3%); p < 0.05. Systemic lupus erythematosus, psoriasis and Hashimoto appeared much more often in the control group. Conclusion: SLIT had no significant effect on the induction of autoimmune diseases.

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来源期刊

Immunotherapy 医学-免疫学

CiteScore

5.00

自引率

3.60%

发文量

113

审稿时长

6-12 weeks

期刊介绍： Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field. Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.