CoVProt:为 COVID-19 蛋白质组学研究与开发建立质谱数据门户网站。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2024-01-01 Epub Date: 2024-01-09 DOI:10.1089/omi.2023.0274
Sakshi Rajoria, Sai Rohith Kavuru, Hari Sundar Pyda, Surbhi Bihani, Dhanush Borishetty, Deeptrup Biswas, Jeel Prajapati, Harshith Paladi, Sanjeeva Srivastava
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引用次数: 0

摘要

2019 年冠状病毒病(COVID-19)大流行在全球范围内造成了严重破坏。除大流行外,严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)病毒对多个器官系统的长期影响仍有待破解。这就需要继续开展系统科学研究。此外,宿主对 SARS-CoV-2 的反应因人而异,导致不同程度的发病和死亡。质谱(MS)已被证明是从全息系统科学角度研究 SARS-CoV-2 的有效手段。为了加强 COVID-19 蛋白质组学研究,我们在此介绍一个基于网络的门户网站 CoVProt。该门户网站的工作正在进行中,旨在全面整理 COVID-19 临床样本的 MS 蛋白质组学数据,为生命科学创新和行星健康研究界提供深入的蛋白质组学研究、数据可视化和便捷的数据访问。目前,CoVProt 包含来自六个数据集的 2725 种不同蛋白质和 37125 种不同肽段的信息,共涉及 202 个临床样本。此外,所有从文献中提取的相关数据集都已使用结合多种工具开发的通用分析管道进行了重新分析。展望未来,我们预计 CoVProt 门户网站还将提供对患者临床参数的访问。CoVProt(v1.0)门户网站填补了研究 COVID-19 宿主蛋白质组学的现有重大空白,据我们所知,这是这方面的首次尝试。我们相信,CoVProt 作为蛋白质组学应用的社区资源将做出贡献,其目标是广泛支持临床研究,促进 COVID-19 生物标记物和具有转化潜力的疗法的发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CoVProt: Toward a Mass Spectrometry Data Portal for COVID-19 Proteomics Research and Development.

The coronavirus disease 2019 (COVID-19) pandemic has wreaked havoc globally. Beyond the pandemic, the long-term effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus in multiple organ systems are yet to be deciphered. This calls for continued systems science research. Moreover, the host response to SARS-CoV-2 varies person-to-person and gives rise to different degrees of morbidity and mortality. Mass spectrometry (MS) has been a proven asset in studies of the SARS-CoV-2 from an omics systems science lens. To strengthen the proteomics research dedicated to COVID-19, we introduce here a web-based portal, CoVProt. The portal is work in progress and aims for a comprehensive curation of MS-based proteomics data of COVID-19 clinical samples for deep proteomic investigations, data visualization, and easy data accessibility for life sciences innovations and planetary health research community. Currently, CoVProt contains information on 2725 different proteins and 37,125 different peptides from six data sets covering a total of 202 clinical samples. Moreover, all pertinent data sets extracted from the literature have been reanalyzed using a common analysis pipeline developed by combining multiple tools. Going forward, we anticipate that the CoVProt portal will also provide access to the clinical parameters of the patients. The CoVProt (v1.0) portal addresses an existing significant gap to study COVID-19 host proteomics, which, to the best of our knowledge, is the first effort in this direction. We believe that CoVProt is poised to make contributions as a community resource for proteomic applications and aims to broadly support clinical studies to facilitate the discovery of COVID-19 biomarkers and therapeutics with translational potential.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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