利用回顾性选通相位对比 MRI 对神经血管顺应性进行量化。

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Marianne Nabbout, Michael C Langham, Christiana Cottrell, Felix W Wehrli
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引用次数: 0

摘要

目的:神经血管顺应性(NVC)是指在心动周期中脑动脉血容量ΔV的变化除以血管内血压ΔP的变化。这项工作的主要目的是评估通过时间分辨测量颈内动脉(ICA)和椎动脉(VA)流速获得的核磁共振成像测量 NVC 的性能。其次,考虑到某些人群(尤其是幼儿)中颈内动脉和椎动脉的横截面较小,我们还想探讨是否可以通过颈总动脉(CCA)的血流,结合事先了解的颈内动脉和椎动脉的平均分流率来估算 NVC。根据单独测量的 CCA 流速以及 ICA/CCA 和 VA/CCA 的平均流速分数(也可从文献数据中获取)进一步估算出 NVC。健康受试者(16 人,女性 8 人,平均年龄 36 ± 13 岁)的 CCA、ICA 和 VA 的时间分辨血流率是在 1.5 T 下通过回顾性门控二维 PC-MRI 获得的。ΔP通过肱压测量确定:结果:实际和估计的平均 NVC 分别为 27 ± 15 和 38 ± 15 μL/mmHg, 两项测量结果具有很强的相关性(r = 0.80; p = 0.0002),测试-重测的类内相关系数分别为 0.964 和 0.899:两种方法的重测精确度都很高。尽管存在较大偏差,但实际 NVC 与估计 NVC 之间具有很强的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Quantification of neurovascular compliance with retrospectively gated phase-contrast MRI.

Quantification of neurovascular compliance with retrospectively gated phase-contrast MRI.

Objective: Neurovascular compliance (NVC) is the change in the brain's arterial tree blood volume, ΔV, divided by the change in intra-vascular blood pressure, ΔP, during the cardiac cycle. The primary aim of this work was to evaluate the performance of MRI measurement of NVC obtained from time-resolved measurements of internal carotid artery (ICA) and vertebral artery (VA) flow rates. A secondary aim was to explore whether NVC could be estimated from common carotid (CCA) flow in conjunction with prior knowledge of mean ICA and VA fractional flow rates, given the small cross-section of ICA and VA in some populations, in particular small children.

Methods: ΔV was quantified from the blood flow rate measured at the ICA and VA for actual NVC derivation. It was further estimated from individually measured CCA flow rate and mean flow fractions ICA/CCA and VA/CCA (which could alternatively be obtained from literature data), to yield estimated NVC. Time-resolved blood flow rate in CCA, ICA and VA was obtained via retrospectively-gated 2D PC-MRI at 1.5 T in healthy subjects (N = 16, 8 women, mean age 36 ± 13 years). ΔP was determined via a brachial pressure measurement.

Results: Actual and estimated mean NVC were 27 ± 15 and 38 ± 15 μL/mmHg, respectively, and the two measurements were strongly correlated (r = 0.80; p = 0.0002) with test-retest intra-class correlation coefficients of 0.964 and 0.899.

Conclusion: Both methods yielded excellent retest precision. In spite of a large bias, actual and estimated NVC were strongly correlated.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
58
审稿时长
>12 weeks
期刊介绍: MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.
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