人源化 "胆汁酸池小鼠肠道微生物群的重要性。

IF 6.7 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Clinical science Pub Date : 2024-01-10 DOI:10.1042/CS20231465

Justine Gillard, Isabelle A Leclercq

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引用次数: 0

摘要

胆汁酸是一种信号介质，能够在组织和肠道微生物群之间进行复杂的交流，并参与了多种免疫和代谢疾病的病理生理学研究。在这篇评论中，我们讨论了肠道微生物群在 Cyp2c70 基因敲除小鼠中的重要性，这种小鼠被认为是研究胆汁酸及其在病理状况中作用的一种很有前途的 "人性化 "实验资源。我们还讨论了 Cyp2c70 基因缺陷小鼠如何有助于提高小鼠模型临床前研究对人类的可转化性。

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Importance of the gut microbiota in mice with a 'humanized' bile acid pool.

Bile acids are signaling mediators, enabling intricate communication between tissues and the gut microbiota, and are involved in the pathophysiology of several immune and metabolic disorders. In this commentary, we discuss the importance of the gut microbiota in the Cyp2c70 knock-out mice, which are considered as a promising 'humanized' experimental resource for studying bile acids and their role in pathological conditions. We also discuss how Cyp2c70-deficient mice contribute to enhancing the translatability of preclinical studies in murine models to humans.

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来源期刊

Clinical science 医学-医学：研究与实验

CiteScore

11.40

自引率

0.00%

发文量

189

审稿时长

4-8 weeks

期刊介绍： Translating molecular bioscience and experimental research into medical insights, Clinical Science offers multi-disciplinary coverage and clinical perspectives to advance human health. Its international Editorial Board is charged with selecting peer-reviewed original papers of the highest scientific merit covering the broad spectrum of biomedical specialities including, although not exclusively: Cardiovascular system Cerebrovascular system Gastrointestinal tract and liver Genomic medicine Infection and immunity Inflammation Oncology Metabolism Endocrinology and nutrition Nephrology Circulation Respiratory system Vascular biology Molecular pathology.