结直肠癌中音速刺猬蛋白的低甲基化

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL

Bangladesh Journal of Medical Science Pub Date : 2024-01-01 DOI:10.3329/bjms.v23i1.70719

Maheera Teli, Madiha Niyaz, Gowhar Rashid, Ishrat Parveiz, R. Wani, Syed Mudassar

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引用次数: 0

摘要

背景：过去的研究表明，音速刺猬（SHH）模式的改变会导致结直肠癌的发生。本研究的目的是确定 SHH 基因启动子低甲基化是否可用于预测罹患结直肠癌的可能性。研究方法在本次调查中，收集了 50 名新确诊和未经治疗的结直肠癌患者的肿瘤样本和周围非肿瘤组织。通过甲基化特异性 PCR（MSP）测定 SHH 甲基化，并将结果与几项临床病理参数相关联。结果显示我们的结果显示，与肿瘤组织相比，正常组织中的 SHH 甲基化水平明显高于肿瘤组织。结论：我们得出结论，SHH 启动子在结直肠癌中甲基化水平较低，这可能会导致正常结肠和直肠细胞癌变。孟加拉国医学科学杂志》第 23 卷第 01 期 January'24 Page : 200-206

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Hypomethylation of Sonic hedgehog in colorectal cancer

Background: Past research has demonstrated that a changed Sonic Hedgehog (SHH) pattern contributes to the development of colorectal cancer. This study’s objective was to determine whether the SHH gene’s promoter hypomethylation might be used to predict the likelihood of developing colorectal cancer. Methods: For the current investigation, 50 newly diagnosed and untreated colorectal cancer patients’ tumor samples and surrounding non-tumor tissues were gathered. SHH methylation was determined by methylation-specific PCR (MSP) and results correlated with several studied clinicopathological parameters. Results: Our results showed that SHH methylation levels are significantly present in normal tissues as compared to tumor tissues. Conclusion: We conclude SHH promoter is hypomethylated in colorectal cancers which may have an effect driving normal colon and rectum cells to cancer. Bangladesh Journal of Medical Science Vol. 23 No. 01 January’24 Page : 200-206

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