T. Swaroop, Rahym Bakyyev, K. Rangappa, Lokman Torun
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Condensation of amines with S-methyl thiouronium salts: an another entry for the synthesis of amidines
In this article, we have presented condensation of primary aryl and alkyl amines with S-methyl thiouronium salts to get N,N,N'-trisubstituted amidines. High yields, short reaction times and fair substrate scope are the noteworthy features of this protocol. Surprisingly, reaction of thiouronium salt with 4-aminopyridine yielded (4-methoxyphenyl)(piperidin-1-yl)methanone.