胺与 S-甲基硫代鎓盐的缩合:合成脒的又一途径

Synlett Pub Date : 2024-01-02 DOI:10.1055/a-2236-9522
T. Swaroop, Rahym Bakyyev, K. Rangappa, Lokman Torun
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引用次数: 0

摘要

本文介绍了伯胺和烷胺与 S-甲基硫代鎓盐缩合得到 N,N,N'-三取代胺的过程。该方案的显著特点是产率高、反应时间短、底物范围广。令人惊奇的是,硫脲盐与 4-氨基吡啶反应生成了 (4-甲氧基苯基)(哌啶-1-基)甲酮。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Condensation of amines with S-methyl thiouronium salts: an another entry for the synthesis of amidines

Condensation of amines with S-methyl thiouronium salts: an another entry for the synthesis of amidines
In this article, we have presented condensation of primary aryl and alkyl amines with S-methyl thiouronium salts to get N,N,N'-trisubstituted amidines. High yields, short reaction times and fair substrate scope are the noteworthy features of this protocol. Surprisingly, reaction of thiouronium salt with 4-aminopyridine yielded (4-methoxyphenyl)(piperidin-1-yl)methanone.
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