通过急诊入院的姑息治疗肿瘤患者的症状、电解质紊乱和血清白蛋白水平:特征和生存结果

IF 1.1 Q4 HEALTH CARE SCIENCES & SERVICES
Mahesh Menon, Subhashini Perumal, Raza Ahmad, Priya Das, Shiv Pratap Singh Rana, Asif Sardar
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引用次数: 0

摘要

我们的研究旨在检查通过急诊住院的姑息治疗肿瘤患者的特征,以了解其症状概况、解淀粉血症和血液检查的特征,以及与死亡率可能存在的关联。经机构审查委员会批准后,我们对本院三级肿瘤专科医院的住院患者进行了一项回顾性观察研究。研究对象为2019年1月至2021年10月期间在姑息治疗下从急诊科入院的癌症患者。由于在此期间所有入院患者都是根据医院COVID-19协议通过急诊入院的,因此研究排除了所有择期入院的患者。收集的数据包括患者特征、血液检查、合并全身性疾病史以及可能与电解质失衡有关的因素。研究期间共收治了 157 名急诊患者,其中大部分是实体瘤患者(92.4%)。疼痛是最常见的主要症状,同时伴有其他症状(68/157)或单独出现(33/157),其次是口服量减少(32/157)和感觉改变(24/157)。在长期随访中,仅有 8 人(5.1%)存活。低钠血症(43%)、低白蛋白血症(66%)和肾功能改变(33.1%)是普遍现象。我们观察到钠水平与预后呈弱正相关(r = 0.199,P = 0.016),白蛋白水平与生存预后呈强正相关(r = 0.329,P = 0.000)。白蛋白正常的患者生存几率更高(几率比:33.1225,95% 置信区间:3.415-321.20,P = 0.003)。这些患者的死亡率很高。低钠血症、低白蛋白血症和肾功能紊乱是常见症状。正常的钠和白蛋白水平与较高的存活几率相关,而血清白蛋白水平的相关性更强。这可能对预后有帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Symptoms, Electrolyte Disturbances and Serum Albumin Levels in Palliative Oncology Patients Admitted Through Emergency: Characteristics and Survival Outcomes
Our research aimed to examine the characteristics of palliative oncology patients hospitalised through an emergency to look for the symptom profile, characteristics of dyselectrolytemia and blood investigations, and possible associations with mortality. After institutional review board approval, a retrospective, observational study of patients hospitalised in our tertiary care specialty oncology hospital was undertaken. Records of hospitalised cancer patients admitted from the emergency department under palliative care from January 2019 to October 2021 were examined. As all admissions during this period were through emergency due to institution COVID-19 protocols, all elective admissions were excluded from the study. Data collected included patient characteristics, blood investigations, and comorbid history of systemic diseases and factors that could be associated with electrolyte imbalance. There were 157 emergency admissions during the study period. A majority were patients with solid tumours (92.4%). Pain was the most frequent cardinal symptom, along with other symptoms (68/157) or in isolation (33/157), followed by reduced oral intake (32/157) and altered sensorium (24/157). sixty-six patients died within the hospitalisation period. On long-term follow-up, only 8 (5.1%) were surviving. Hyponatraemia (43%), Hypoalbuminaemia (66%), and altered renal function (33.1%) were prevalent. We observed a weak positive correlation between sodium levels and outcome (r = 0.199, P = 0.016) and a strong positive correlation between albumin levels and survival outcomes (r = 0.329, P = 0.000). Patients with normal albumin had a higher chance of survival (odds ratio: 33.1225, 95% confidence interval: 3.415–321.20, P = 0.003). Pain-reduced oral intake and altered sensorium are common emergency symptoms in oncology palliative care. Mortality is high in these patients. Hyponatraemia, hypoalbuminaemia, and deranged renal functions were commonly seen. Normal sodium and albumin levels were associated with higher chances of survival, and the association was strong for serum albumin levels. This may have prognostic utility.
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来源期刊
Indian Journal of Palliative Care
Indian Journal of Palliative Care HEALTH CARE SCIENCES & SERVICES-
CiteScore
2.30
自引率
0.00%
发文量
57
期刊介绍: Welcome to the website of the Indian Journal of Palliative Care. You have free full text access to recent issues of the journal. The links connect you to •guidelines and systematic reviews in palliative care and oncology •a directory of palliative care programmes in India and IAPC membership •Palliative Care Formulary, book reviews and other educational material •guidance on statistical tests and medical writing.
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