尿镉与骨折、骨质流失和肌肉流失风险的前瞻性研究方案

IF 3.4 Q2 ENDOCRINOLOGY & METABOLISM
JBMR Plus Pub Date : 2024-01-04 DOI:10.1093/jbmrpl/ziad006
Christopher de la Bastide, Lissa Soares, L. Lui, James Harrington, Peggy Cawthon, Eric Orwoll, Deborah Kado, Jaymie Meliker
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引用次数: 0

摘要

镉(Cd)是一种重金属,是土壤和农作物中的天然元素,其浓度的增加与施用磷肥和农田污水污泥有关。据记录,美国大部分老年男性和女性都接触过镉。事实证明,接触镉会引起健康问题,如吸入镉会导致肺癌风险和肾功能受损,但越来越多的证据表明,镉还会影响骨骼和肌肉健康。鉴于低水平的镉可能会影响骨骼和肌肉,我们设计了前瞻性研究,利用美国两项规模最大、最详细的老年男性和女性骨骼健康研究:男性骨质疏松性骨折(MrOS)研究和骨质疏松性骨折(SOF)研究。尿镉(U-Cd)是长期镉暴露的替代物,我们正在研究尿镉(U-Cd)与骨骼和肌肉健康的关系。在机理研究和横断面研究的提示性证据的基础上,这将是第一项关于骨折事件、骨质流失和肌肉流失与尿镉的关系的有力的前瞻性研究,尿镉是长期镉暴露的既定生物标志物。以下是拟进行的研究的拟议方案;如果成功,拟议的研究可能会对指导美国未来的政策产生影响,以减少美国人口的镉暴露量,类似于欧盟最近通过的限制化肥中镉含量的政策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A protocol for the prospective study of urinary cadmium with risk of fracture, bone loss, and muscle loss
Cadmium (Cd) is a heavy metal and natural element found in soil and crops with increasing concentrations linked to phosphate fertilizers and sewage sludge applied to crop lands. A large fraction of older U.S men and woman have documented Cd exposure. Cd exposure has proven health concerns such as risk of lung cancer from inhalation and impaired renal function, however, growing evidence suggests it also influences bone and muscle health. Given that low levels of Cd could affect bone and muscle, we have designed prospective studies using the two largest and most detailed U.S. studies of bone health in older men and women: The Osteoporotic Fractures in Men (MrOS) Study and the Study of Osteoporotic Fractures (SOF). We are investigating the association of urinary cadmium (U-Cd), as a surrogate for long term cadmium exposure, with bone and muscle health. Building off suggestive evidence from mechanistic and cross-sectional studies, this will be the first well-powered prospective study of incident fracture outcomes, bone loss, and muscle loss in relation to U-Cd, an established biomarker of long-term Cd exposure. The following is a proposed protocol for the intended study; if successful the proposed studies could be influential in directing future U.S policy to decrease Cd exposure in the U.S population similar to recent policies adopted by the European Union to limit Cd in fertilizers.
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来源期刊
JBMR Plus
JBMR Plus Medicine-Orthopedics and Sports Medicine
CiteScore
5.80
自引率
2.60%
发文量
103
审稿时长
8 weeks
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