R. Mudd, M. Reid, Laura C. Paterson, J. Atzrodt, V. Derdau, William J. Kerr
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Directing Hydrogen Isotope Exchange with Aryl Carboxylic Acids
A highly effective and selective ortho-directed hydrogen isotope exchange process for aryl carboxylic acids has been achieved using an iridium(I) N-heterocyclic carbene/phosphine complex under mild and neutral conditions. Good levels of deuterium incorporation have been delivered across a wide array of examples, including within a number of biologically active drug compounds.