探索阿奇霉素乳膏治疗癌症患者由紫杉类药物引起的周围神经病变的有效性:一项试点、随机和双盲临床试验

IF 1.1 Q4 HEALTH CARE SCIENCES & SERVICES
G. Heydarirad, Hamid Reza Mirzaei, Reyhaneh Gharehgozlou, J. Buentzel, M. R. Namazi, M. Pasalar
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引用次数: 0

摘要

化疗引起的周围神经病变是接受各种化疗方案的癌症患者中常见的一种疾病。本研究旨在探讨大黄素(Trachyspermum ammi [L.] Sprague)乳膏治疗由紫杉类化疗药物引发的周围神经病变症状的可行性。这是一项试验性、双盲和随机临床试验,对象是 2021-2022 年期间在德黑兰接受紫杉类药物化疗的周围神经病变患者。患者接受阿奇霉素或安慰剂药膏治疗四周,并在试验开始和结束时填写化疗引起的周围神经病变评估工具(CIPNAT)。30名乳腺癌、肺癌、胃肠道癌或前列腺癌患者分别被分配到药物组和安慰剂组。两组间的 CIPNAT 评分平均值相差 0.83,表明药物与安慰剂相比在统计学上无效(P = 0.372)。尽管阿奇霉素软膏在治疗化疗引起的周围神经病变症状方面的疗效令人无法接受,但要得出全面的推论,必须进行多中心对照试验,并有足够的样本量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the Effectiveness of Ajwain Cream in Treating Taxane-induced Peripheral Neuropathy in Cancer Patients: A Pilot, Randomised and Double-blind Clinical Trial
Chemotherapy-induced peripheral neuropathy is a common disorder among cancer patients receiving various chemotherapeutic protocols. The present study aimed to explore the feasibility of ajwain (Trachyspermum ammi [L.] Sprague) cream in treating peripheral neuropathy symptoms triggered by taxane chemotherapeutic agents. This was a pilot, double-blind, and randomised clinical trial on patients with peripheral neuropathy attributable to chemotherapy with taxane drugs during 2021–2022 in Tehran. Patients received ajwain or placebo cream for four weeks and filled out the chemotherapy-induced peripheral neuropathy assessment tool (CIPNAT) at the start and end finale of the trial. Side effects were also noted. Thirty patients suffering from breast, lung, gastro-intestinal, or prostate cancer were allocated to each of the drug and placebo groups. The mean difference in CIPNAT score between the groups was 0.83, demonstrating the statistical ineffectiveness of the drug compared with the placebo (P = 0.372). The safety profile showed promising outcomes at the end of the trial. Although the effectiveness of ajwain cream was unacceptable in treating chemotherapy-induced peripheral neuropathy symptoms, multicentre controlled trials with ample sample size are mandatory for an all-inclusive inference.
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来源期刊
Indian Journal of Palliative Care
Indian Journal of Palliative Care HEALTH CARE SCIENCES & SERVICES-
CiteScore
2.30
自引率
0.00%
发文量
57
期刊介绍: Welcome to the website of the Indian Journal of Palliative Care. You have free full text access to recent issues of the journal. The links connect you to •guidelines and systematic reviews in palliative care and oncology •a directory of palliative care programmes in India and IAPC membership •Palliative Care Formulary, book reviews and other educational material •guidance on statistical tests and medical writing.
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