Synthetic methodologies to access bioactive bis-coumarin scaffold: a recent progress

Abstract Heterocyclics particularly those containing oxygen and nitrogen atoms are unique precursors for the synthesis of various agrochemicals and pharmaceuticals. Bis-coumarins are well-known oxygen-containing heterocycles of great significance. The development of methods to prepare bis-coumarins is of great interest in synthetic organic chemistry because of their versatile importance in medicinal chemistry and chemical biology. Bis-coumarins are well known for their antibiotic, antimicrobial, anti-HIV, and antitumor activity. Due to the vast application of bis-coumarins, the synthesis of these heterocycles has attracted huge interest from researchers. In this review, we have summarized the diverse synthetic routes of bis-coumarin synthesis making use of different catalysts and solvents under versatile reaction conditions.