透皮给药系统的当前趋势和最新发展 TDDS

Devbrat Soni, Kartikay Prakash, Kashif Shakeel, Priyanka Kesharawani
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引用次数: 0

摘要

TDDS 的基本目标是以预定的速度通过皮肤将药物注入全身循环,患者之间和患者内部的差异很小。TDDS 有多种形式,包括储液器和基质系统、粘合剂中的单层药物和粘合剂中的多层药物。目前已有超过 35 种产品获准在美国销售,约有 16 种活性成分获准在国际上用作 TDDS,TDDS 产品的市场价值正在迅速增长。透皮给药系统(TDDS)由于患者排斥的可能性低、给药简单、患者使用方便且持之以恒,因此是传统针剂注射的理想替代品。然而,透皮给药非常复杂,而且受到皮肤理化特性的限制。本研究介绍了目前可以使用的多种透皮给药方法,以及它们各自的优缺点、表征技术和潜力。透皮贴片是一种顽固的医疗贴片,贴在皮肤上,通过皮肤将特定数量的药物注入血液,不断加速受损身体部位的修复。透皮给药是一项相当新的技术,在提供广泛的特定服务时,可以减少对针头的需求,但成本是需要考虑的基本要素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current Trends and Recent Development of Transdermal Drug Delivery System TDDS
The basic goal of TDDS is to administer medications at a predefined pace into systemic circulation through the skin with little inter- and intrapatient variance. TDDS come in a variety of forms, including reservoir and matrix systems, single-layer drugs in adhesive, and multi-layer drugs in adhesive. With more than 35 items already authorised for sale in the US and around 16 active components authorised for use as TDDSs internationally, the market value of TDDS products is growing quickly. Due to its low likelihood of patient rejection, simplicity of administration, and patients' convenience and perseverance, a transdermal drug delivery system [TDDS] is a desirable substitute for traditional needle injections. However, transdermal administration is complicated and constrained by the physicochemical characteristics of the skin. The many types of TDDS approaches that are now accessible are covered in this study, along with their individual benefits and drawbacks, characterization techniques, and potential. A transdermal patch is an tenacious medical patch that's applied to the skin to administer a particular quantum of drug via the skin and into the bloodstream, constantly accelerating the mending of a damaged body part. Transdermal medicine administration is a fairly new technology that has the implicit to reduce the need for needles when furnishing a wide range of specifics, but the cost is an essential element to take into account.
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