带有恶性间质成分的雌性犬乳腺肿瘤解剖病理特征和 COX-2 表达的比较分析

K. S. Prates, Priscilla L. Oliveira, T. S. Bueno, Karine A. Damasceno, D. Driemeier, L. Sonne, S. Pavarini, A. Bertagnolli
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引用次数: 0

摘要

摘要:具有恶性间质成分的犬乳腺肿瘤(如癌肉瘤和肉瘤)属于不常见的组织学异质性肿瘤。人们对这些组织变异的生物学行为知之甚少。本研究旨在比较不同组织学亚型癌肉瘤和肉瘤的临床病理特征和COX-2免疫组化表达。研究选取了雌性犬乳腺中的 23 个癌肉瘤和 15 个肉瘤样本。研究人员查阅了医疗记录,以获取临床数据。随后,对组织学显微镜切片进行分析,以评估间质亚型、坏死、血管侵犯、组织学分级和淋巴结转移。免疫组化用于评估 COX-2 的表达。恶性间质增生分为骨肉瘤(23/40)、纤维肉瘤(5/40)、脂肪肉瘤(6/40)和软骨肉瘤(4/40)。骨肉瘤分化是肉瘤和癌肉瘤中最主要的类型,与血管侵犯(P=0.010)和淋巴结转移(P=0.014)有关。在14.3%的癌肉瘤(癌细胞和/或肉瘤细胞)和27.3%的肉瘤中检测到COX-2高表达。癌肉瘤和肉瘤具有相似的临床和病理特征,肿瘤体积大,瘤内坏死,组织学分级高,但血管侵犯和淋巴结转移的频率较低。骨肉瘤亚型比非骨肉瘤亚型更具侵袭性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A comparative analysis of anatomopathological features and COX-2 expression of mammary neoplasms with malignant mesenchymal components in female dogs
ABSTRACT: Canine mammary neoplasms with malignant mesenchymal components, such as carcinosarcomas and sarcomas, belong to an uncommon and histologically heterogeneous group. Little is known about the biological behavior of these histogenic variants. This study aimed to compare the clinicopathological characteristics and the COX-2 immunohistochemical expression of different histologic subtypes of carcinosarcomas and sarcomas. Samples of 23 carcinosarcomas and 15 sarcomas from the mammary glands of female dogs were studied. Medical records were reviewed to obtain clinical data. Subsequently, histology microscope slides were analyzed to assess for mesenchymal subtypes, necrosis, vascular invasion, histologic grades, and lymph node metastasis. Immunohistochemistry was used to assess the COX-2 expression. The malignant mesenchymal proliferation was categorized into osteosarcomas (23/40), fibrosarcomas (5/40), liposarcomas (6/40) and chondrosarcomas (4/40). The osteosarcomatous differentiation was the most predominant type among the sarcomas and carcinosarcomas and was associated with vascular invasion (P=0.010) and lymph node metastases (P=0.014). High COX-2 expression was detected in 14.3% of the carcinosarcomas (carcinoma and/or sarcoma cells) and 27.3% of the sarcomas. The carcinosarcomas and sarcomas had similar clinical and pathological characteristics and developed as large tumors, with intratumoral necrosis and a predominance of high histologic grades, although the frequency of vascular invasion and lymph node metastasis was low. Osteosarcoma subtypes presented more aggressive characteristics than non-osteosarcoma subtypes.
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