{"title":"掺入 137cs 影响下的睾丸组织氧气吸收指标","authors":"Mohanad A. Al Meselmani","doi":"10.18499/2070-9277-2023-26-2-92-100","DOIUrl":null,"url":null,"abstract":"The results of assessing the effect of caesium-137 radionuclide, with a specific activity of 3300 Bq/kg, on oxygen consumption by rat testicular tissues. A significant increase in the rate of oxygen consumption was demonstrated on both endogenous and exogenous substrates. The maximum increase in tissue respiration was noted against the background of the use of glutamate as an exogenous substrate. Signs of disconnection of oxidative phosphorylation processes with the use of 2,4-dinitrophenol have been recorded, as well as inhibitory analysis confirms a decrease in the intensity of NAD-dependent oxidation Thus, the oral intake of caesium-137 into the body of rats with a specific activity of 3300 Bq / kg poses a danger to the male reproductive system.","PeriodicalId":503589,"journal":{"name":"Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)","volume":"412 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"INDICATORS OF OXYGEN ABSORPTION IN TESTICULAR TISSUES UNDER THE INFLUENCE OF INCORPORATION 137CS\",\"authors\":\"Mohanad A. Al Meselmani\",\"doi\":\"10.18499/2070-9277-2023-26-2-92-100\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The results of assessing the effect of caesium-137 radionuclide, with a specific activity of 3300 Bq/kg, on oxygen consumption by rat testicular tissues. A significant increase in the rate of oxygen consumption was demonstrated on both endogenous and exogenous substrates. The maximum increase in tissue respiration was noted against the background of the use of glutamate as an exogenous substrate. Signs of disconnection of oxidative phosphorylation processes with the use of 2,4-dinitrophenol have been recorded, as well as inhibitory analysis confirms a decrease in the intensity of NAD-dependent oxidation Thus, the oral intake of caesium-137 into the body of rats with a specific activity of 3300 Bq / kg poses a danger to the male reproductive system.\",\"PeriodicalId\":503589,\"journal\":{\"name\":\"Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)\",\"volume\":\"412 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18499/2070-9277-2023-26-2-92-100\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18499/2070-9277-2023-26-2-92-100","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
比活度为 3300 Bq/kg 的铯-137 放射性核素对大鼠睾丸组织耗氧量影响的评估结果。结果表明,在内源性和外源性底物的作用下,大鼠睾丸组织的耗氧量明显增加。在使用谷氨酸作为外源底物的情况下,组织呼吸的增加幅度最大。使用 2,4-二硝基苯酚后,氧化磷酸化过程出现了中断迹象,抑制分析也证实了 NAD 依赖性氧化作用强度的下降。
INDICATORS OF OXYGEN ABSORPTION IN TESTICULAR TISSUES UNDER THE INFLUENCE OF INCORPORATION 137CS
The results of assessing the effect of caesium-137 radionuclide, with a specific activity of 3300 Bq/kg, on oxygen consumption by rat testicular tissues. A significant increase in the rate of oxygen consumption was demonstrated on both endogenous and exogenous substrates. The maximum increase in tissue respiration was noted against the background of the use of glutamate as an exogenous substrate. Signs of disconnection of oxidative phosphorylation processes with the use of 2,4-dinitrophenol have been recorded, as well as inhibitory analysis confirms a decrease in the intensity of NAD-dependent oxidation Thus, the oral intake of caesium-137 into the body of rats with a specific activity of 3300 Bq / kg poses a danger to the male reproductive system.