Asparagus gonoclados Baker (AGAF) Root Tubers Improve Glycemic Control and Hyperlipidemia in Streptozotocin-Induced Diabetic Rats

Abstract This study aimed to investigate the antidiabetic and antihyperlipidemic activity of the active fraction of Asparagus gonoclados root tubers (AGAF) in streptozotocin-induced diabetic rats. After 45 days of treatment with the active fraction (AGAF) of Asparagus gonoclados at a dose of 50 mg/kg b.w.t., the levels of fasting blood glucose (FBG), hemoglobin, HbA1c, insulin, serum lipid profiles, and renal and hepatic function markers were measured in all experimental groups of rats. Treatment with AGAF remarkably normalized the FBG, insulin, and lipid profile levels. AGAF also normalized the hepatic and renal function markers in STZ-induced diabetic-treated rats. The findings from our current study confirm that AGAF successfully alleviates diabetes mellitus and its associated complications by improving insulin secretion and action with no apparent toxic effects on the liver or kidney. GRAPHICAL ABSTRACT