用于局部给药抗菌药物的固体脂质纳米粒子的制备与表征

Pandey Ak
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引用次数: 0

摘要

本研究旨在制备和评估用于皮肤给药环丙沙星的固体脂质纳米颗粒。通过使用微乳液技术,成功研制出了负载环丙沙星的固体脂质纳米颗粒(SLNs)。结果发现,不同成分的用量对环丙沙星的负载能力、平均粒径、电荷粒径分布、形态以及药物与脂质的相容性都有很大影响。在优化的工艺条件下,负载环丙沙星的 SLN 呈球形颗粒,平均粒径为 250 ɳm,环丙沙星的掺入率达到 60%。这种 SLN 在体外可持续释放药物 6 小时。结果表明,该制剂可用作治疗真菌感染的潜在外用制剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Formulation and Characterization of Solid Lipid Nanoparticles for Topical Delivery of Antibacterial Drug
The aim of this study was to prepare and evaluate solid lipid nanoparticles for the skin delivery of Ciprofloxacin. Ciprofloxacin loaded solid lipid nanoparticles (SLNs) have been successfully developed by using a microemulsion technique. Three different formulations were prepared It was found that variation in the amount of ingredients had profound effects on the Ciprofloxacin loading capacity, mean particle size, size distribution of charge, morphology, and drug-lipid compatibility. At optimized process conditions, Ciprofloxacin loaded SLNs showed spherical particles with a mean particle size of 250 ɳm and 60% Ciprofloxacin incorporation efficacy was achieved. The SLN sustained the drug release for 6 h in vitro. The results suggest formulation could be used as a potential topical formulation for fungal infection.
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