通过实验设计(DOE)和体外表征研究抗炎镇痛药物依托考昔

Ramarao Cht
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引用次数: 0

摘要

目的是研究通过粘合剂、崩解剂和β-环糊精提高依托考昔的药物释放。采用设计专家软件(DOE)进行两级因子设计;3 个独立中心点。对制备的颗粒和片剂进行了流动性、物理特性和溶解度测试。优化配方有 4 个自变量 Y1(DR 30)、Y2(DR 60)、Y3(DR 90)、Y4(T50 30)、Y5(DE10)。DoE 用于绘制响应面图、优化和可取性以及方差分析(ANOVA),P <0.005 表明响应(因变量)Y1、Y2、Y3、Y4 和 Y5 的方差分析具有显著性。采用 PVP 作为粘合剂(因素 A)和马铃薯淀粉作为崩解剂(因素 B)配制的配方 Fa 在 1 小时内的药物释放率最高,达到 95%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Anti-Inflammatory and Analgesic Drug Etoricoxib Investigated by Design of Experimentation (DOE) and in Vitro Characterization
The objective studies enhance drug release of etoricoxib by Binders, disintegrant& β- Cyclodextrin. The 2 level factorial designs employing (DOE) Design expert software; 3 independent with 3 central points. The prepared granules and tablets were subjected to flow, physical characteristics and dissolution. The optimized formulation exhibited 4 independent variables Y1 (DR 30), Y2 (DR 60), Y3 (DR 90) Y4 (T50 30), Y5 (DE10). DoE used to find response surface plots, optimization and Desirability and analysis of variance (ANOVA), p <0.005 indicates that the ANOVA of responses (dependent variables) Y1, Y2, Y3, Y4& Y5 is significant. The formulation Fa, formulated employing PVP as binder (factor A) and potato starch as disintegrant (factor B) had the highest drug release rate of 95 % in 1 h. The desirability function was 0.90170 and the predicted and experimental values had strong correlations.
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