{"title":"通过实验设计（DOE）和体外表征研究抗炎镇痛药物依托考昔","authors":"Ramarao Cht","doi":"10.23880/beba-16000212","DOIUrl":null,"url":null,"abstract":"The objective studies enhance drug release of etoricoxib by Binders, disintegrant& β- Cyclodextrin. The 2 level factorial designs employing (DOE) Design expert software; 3 independent with 3 central points. The prepared granules and tablets were subjected to flow, physical characteristics and dissolution. The optimized formulation exhibited 4 independent variables Y1 (DR 30), Y2 (DR 60), Y3 (DR 90) Y4 (T50 30), Y5 (DE10). DoE used to find response surface plots, optimization and Desirability and analysis of variance (ANOVA), p <0.005 indicates that the ANOVA of responses (dependent variables) Y1, Y2, Y3, Y4& Y5 is significant. The formulation Fa, formulated employing PVP as binder (factor A) and potato starch as disintegrant (factor B) had the highest drug release rate of 95 % in 1 h. The desirability function was 0.90170 and the predicted and experimental values had strong correlations.","PeriodicalId":8995,"journal":{"name":"Bioequivalence & Bioavailability International Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An Anti-Inflammatory and Analgesic Drug Etoricoxib Investigated by Design of Experimentation (DOE) and in Vitro Characterization\",\"authors\":\"Ramarao Cht\",\"doi\":\"10.23880/beba-16000212\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The objective studies enhance drug release of etoricoxib by Binders, disintegrant& β- Cyclodextrin. The 2 level factorial designs employing (DOE) Design expert software; 3 independent with 3 central points. The prepared granules and tablets were subjected to flow, physical characteristics and dissolution. The optimized formulation exhibited 4 independent variables Y1 (DR 30), Y2 (DR 60), Y3 (DR 90) Y4 (T50 30), Y5 (DE10). DoE used to find response surface plots, optimization and Desirability and analysis of variance (ANOVA), p <0.005 indicates that the ANOVA of responses (dependent variables) Y1, Y2, Y3, Y4& Y5 is significant. The formulation Fa, formulated employing PVP as binder (factor A) and potato starch as disintegrant (factor B) had the highest drug release rate of 95 % in 1 h. The desirability function was 0.90170 and the predicted and experimental values had strong correlations.\",\"PeriodicalId\":8995,\"journal\":{\"name\":\"Bioequivalence & Bioavailability International Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioequivalence & Bioavailability International Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23880/beba-16000212\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioequivalence & Bioavailability International Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23880/beba-16000212","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
An Anti-Inflammatory and Analgesic Drug Etoricoxib Investigated by Design of Experimentation (DOE) and in Vitro Characterization
The objective studies enhance drug release of etoricoxib by Binders, disintegrant& β- Cyclodextrin. The 2 level factorial designs employing (DOE) Design expert software; 3 independent with 3 central points. The prepared granules and tablets were subjected to flow, physical characteristics and dissolution. The optimized formulation exhibited 4 independent variables Y1 (DR 30), Y2 (DR 60), Y3 (DR 90) Y4 (T50 30), Y5 (DE10). DoE used to find response surface plots, optimization and Desirability and analysis of variance (ANOVA), p <0.005 indicates that the ANOVA of responses (dependent variables) Y1, Y2, Y3, Y4& Y5 is significant. The formulation Fa, formulated employing PVP as binder (factor A) and potato starch as disintegrant (factor B) had the highest drug release rate of 95 % in 1 h. The desirability function was 0.90170 and the predicted and experimental values had strong correlations.
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