脂肪组织衍生间充质干：在肥胖症和 2 型糖尿病发病机制中的作用

Q3 Medicine

Obesity and Metabolism Pub Date : 2023-07-27 DOI:10.14341/omet12985

E. G. Uchasova, Yuliya A Dyleva, E. Belik, O. Gruzdeva

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引用次数: 0

摘要

脂肪组织间充质干是一种成体干细胞，与其他来源的间充质干细胞一样，具有多能能力和免疫调节特性。大量研究表明，脂肪组织干细胞参与病理过程，可表现出促炎特性，并吸引附近的炎性免疫细胞。随后，炎症创造了一个导致脂肪组织功能障碍的微环境。肥胖症和 2 型糖尿病就是这种过程的例子，在肥胖症和 2 型糖尿病中，脂肪生成受到破坏，并引发胰岛素抵抗。本综述旨在了解脂肪组织干细胞在肥胖症和2型糖尿病发病机制中的作用。

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Adipose tissue — derived mesenchymal stem: a role in the pathogenesis of obesity and type 2 diabetes mellitus

Adipose tissue-derived mesenchymal stem are adult stem cells endowed with multipotent abilities and immunomodulatory properties, like mesenchymal stem cells of other origins. Numerous studies show that adipose tissue stem cells are involved in the pathological process and can exhibit pro-inflammatory properties and attract inflammatory immune cells in the neighborhood. Subsequently, inflammation creates a microenvironment leading to adipose tissue dysfunction. Examples of such a process are obesity and type 2 diabetes mellitus, in which adipogenesis is disrupted and insulin resistance is initiated. The aim of this review is to understand the role of adipose tissue stem cells in the pathogenesis of obesity and type 2 diabetes mellitus.

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来源期刊

Obesity and Metabolism Medicine-Internal Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Journal "Obesity and Metabolism" is a multidisciplinary forum for clinical and applied research in the field of biochemistry, physiology, pathophysiology, genetics, nutrition, as well as molecular, metabolic, psychological and epidemiological aspects of obesity and metabolism. The main subject "Metabolism" reviewed in the journal, includes fat, carbohydrate, protein, bone, fluid and electrolyte and other types of metabolism in the spectrum of pathology of the endocrine system. The priority direction of Journal "Obesity and Metabolism" is publishing modern high-quality original research on the effectiveness of new and existing treatments in any aspect of metabolic and endocrine diseases. Pre-clinical pharmacology, pharmacokinetics studies, meta-analyzes, addressed to drug safety and tolerance are also welcome for publication in the journal "Obesity and metabolism." Journal "Obesity and Metabolism" announces review articles that are balanced, clear and offer the reader a modern and critical analysis of the literature on the subject of the magazine. Case reports, and lecture materials are also published for highlighting for practitioners new approaches to diagnosis and treatment of patients with metabolic disorders and obesity.