脑性视力障碍的神经可塑性

S. Salmanova, E. Kasimov
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摘要

导言。小儿脑卒中领域发展迅速,目前已到了需要重点资助以取得进一步进展的阶段,包括对机制的理解和最佳治疗方法。该领域的研究人员积极进取、通力合作,为提高研究效率提供了巨大的潜力。近年来,在研究产前和围产期脑病患儿脑视力障碍(CVI)的动态变化时,研究一直在向研究中枢血流动力学、全身和局部脑内循环以及眼眶和眼内血流动力学的方向扩展。本研究的目的是研究 NE 患儿在颅内血流动力学和液体动力学紊乱恢复阶段的神经可塑性与脑视力障碍之间的关系机制。材料和方法。在过去的 10 年中,在儿童神经病医院、共和国围产中心和儿科研究所的帮助和合作下,我们对 3,500 名 3 个月至 6 岁的儿童进行了检查,其中 1,500 名儿童在新生儿期被诊断为急性脑血管意外。平衡指标--血液中的儿茶酚胺、尿液中的排泄物、血液中的糖和皮质醇、血浆和红细胞中的电解质。NSG、MRI、CDU。脑电图(睡眠节律、情绪和运动活动)结果。事实证明,康复选择的决定性机制取决于下丘脑-垂体关系的方向和平衡失调的性质。在这些儿童中,绝大多数都在这些漫长的岁月里经历过儿茶酚胺兴奋倾倒综合征,并同时具有大脑病理学和 CVI 的临床表现。通过绘制直方图,可以确定胆碱能机制对一般血液动力学的影响不如对眶内血液循环的影响明显。换句话说,通过评估血液动力学对刺激的反应,可以发现颅内血液动力学指数的波动比一般血液动力学指数的波动更明显。结论方差分析证明,平均动态血压的稳定性是稳定中枢神经系统和视觉分析仪适应性平衡神经可塑性的主要机制之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
NEUROPLASTICITY IN CEREBRAL VISUAL IMPAIRMENT
Introduction. The field of pediatric stroke has developed rapidly and has reached the stage where focused funding prioritization is required to make further advances including understanding mechanisms and optimal treatments. The existence of highly motivated and collaborative researchers in this field provides tremendous potential for leveraging research productivity. In recent years, research has been expanding in the direction of studying central hemodynamics, general and local intracerebral circulation, as well as orbital and intraocular hemodynamics when studying the dynamics of cerebral visual impairment (CVI) in children with pre- and perinatal encephalopathy. The aim of the study was studying the mechanisms of the relationship between neuroplasticity and cerebral visual impairment at the recovery stages of intracranial hemodynamic and liquor dynamic disturbances in children with NE. Materials and methods. Over the past 10 years, out of 3,500 children aged from 3 months to 6 years examined by us, with the help and cooperation of the children's neurological hospital, the Republican Perinatal Center and the Research Institute of Pediatrics, 1,500 children were diagnosed with acute cerebrovascular accident in the neonatal period of life. Homeostasis indicators-catecholamines in the blood, excretion in the urine, the sugar and cortisol in the blood, electrolytes in plasma and erythrocytes. NSG, MRI, CDU. The reactivity of BP, of the pulse and respiration to vegetotropic drugs and PA.EEG (sleep rhythm, emotional and motor activity) Results. It has been proven that the decisive mechanisms of recovery options depend on the orientation of the hypothalamic-pituitary relationship and the nature of homeostatic aberrations. The overwhelming majority of these children have experienced catecholamine excite dumping syndrome over these long years and had a clinical picture of both cerebral pathology and CVI. By compiling histograms, it was possible to establish that the effect of cholinergic mechanisms on general hemodynamics was less pronounced than on intraorbital blood circulation. In other words, the assessment of hemodynamic responsiveness to the stimulus revealed a more significant fluctuation in the index of intracranial rather than general hemodynamics. Conclusion. Analysis of variance proves that the stability of the mean dynamic blood pressure is one of the leading mechanisms for stabilization of adaptive homeostatic neuroplasticity of the CNS and visual analyzer.
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