Evaluation of the Efficacy of Ciprofloxacin as Topical Adjunctive Therapy in Non-Surgical Treatment of Stage I and II Grade A Periodontitis (Clinical and Biochemical Study)

Aims: This study was performed to evaluate clinically and biochemically the efficacy of ciprofloxacin as adjunctive in non-surgical treatment of stage I and II Grade A periodontitis, through evaluation of the clinical parameters as well as IL-6 level in GCF. . Subjects and Methods: 20 patients of both sex divided into two groups. Group 1 included 10 patients were treated by only conventional periodontal therapy (scaling and root planing). Group 2 included 10 patients were treated by scaling and root planing followed by topical intra pocket application of Ciprofloxacin gel 1%. Evaluated clinically at baseline, 1 month and 3 months. The biochemical evaluation of interleukin 6 was done at baseline, 1 month and 3 months. Results: Clinical parameter showed a statistically significant differences in both groups at the different intervals when compared to the baseline. All parameter showed in group 2 statistically significant difference between 1 month and 3 month. When groups 2 was compared to group 1 all parameter showed statistically reduction at 1 month and 3 months in relation to baseline. Biochemical marker showed a statistically significant differences were showed in both groups at the different intervals when compared to the baseline with statistically significant difference between 1 month and 3 month. Conclusion: The topically applied ciprofloxacin seamed to exhibit a synergistic action in treatment of stage I and II grade A periodontitis.