M. A. Merkulova, N. S. Osipova, A. V. Kalistratova, Yu. V. Ermolenko, S. E. Gel’perina
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引用次数: 0
摘要
本综述的重点是基于胶体载体（即由合成聚合物和天然聚合物制成的纳米颗粒和胶束）的依托泊苷给药系统。依托泊苷是一种拓扑异构酶 II 抑制剂，在多种肿瘤的化疗中占有重要地位；然而，由于其严重的副作用，其使用往往受到限制。胶体给药系统的应用可以改变依托泊苷的药代动力学参数，增加其在肿瘤中的蓄积，从而提高抗肿瘤效果。特别值得关注的是对肿瘤微环境中的特定条件做出反应的刺激敏感系统，它可以显著提高药物的选择性。
Etoposide-Loaded Colloidal Delivery Systems Based on Biodegradable Polymeric Carriers
The review is focused on the etoposide delivery systems based on colloidal carriers, i.e., nanoparticles and micelles made of synthetic and natural polymers. Etoposide, a topoisomerase II inhibitor, occupies an important place in the chemotherapy of a number of tumors; however, its use is often limited due to severe side effects. The application of colloidal delivery systems makes it possible to change the pharmacokinetic parameters of etoposide and increase its accumulation in tumors leading to an increase in the antitumor effect. Of particular interest are stimuli-sensitive systems that respond to specific conditions in the tumor microenvironment, which can significantly increase the selectivity of the drug.
期刊介绍：
Colloid Journal (Kolloidnyi Zhurnal) is the only journal in Russia that publishes the results of research in the area of chemical science dealing with the disperse state of matter and surface phenomena in disperse systems. The journal covers experimental and theoretical works on a great variety of colloid and surface phenomena: the structure and properties of interfaces; adsorption phenomena and structure of adsorption layers of surfactants; capillary phenomena; wetting films; wetting and spreading; and detergency. The formation of colloid systems, their molecular-kinetic and optical properties, surface forces, interaction of colloidal particles, stabilization, and criteria of stability loss of different disperse systems (lyosols and aerosols, suspensions, emulsions, foams, and micellar systems) are also topics of the journal. Colloid Journal also includes the phenomena of electro- and diffusiophoresis, electro- and thermoosmosis, and capillary and reverse osmosis, i.e., phenomena dealing with the existence of diffusion layers of molecules and ions in the vicinity of the interface.
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