Comparative Study of Nd: YAG Laser and Platelet-Rich Plasma (PRP) in the Treatment of Periodontitis Using a Split-Mouth Design

Aim: This study aimed to compare the efficacy of ND: YAG laser and PRP in the treatment of chronic periodontitis using a split-mouth design. Subjects and Methods: A randomized clinical trial was conducted on 30 patients diagnosed with chronic periodontitis. Each patient received ND: YAG laser treatment on one side of the mouth and PRP on the other. Clinical parameters include Probing Depth (PD), and Gingival Index (GI). Clinical Attachment Level (CAL), Plaque Index (PI), and radiographic bony defect were assessed at baseline, 1 month, and 6 months post-treatment. The Mann-Whitney U test was used for statistical analysis. Results: Treatment with the ND: YAG laser led to a significantly larger decrease in all clinical parameters when contrasted with the PRP treatment. This was statistically significant at both the 1-month and 6-month post-treatment evaluations (p\<0.001). Those who received ND: YAG laser treatment showed reductions in PD, GI, CAL, PI, and radiographic bony defects. Conclusion: The ND YAG laser treatment demonstrated superior efficacy over PRP in the management of chronic periodontitis. These findings suggest that the ND YAG laser could be a more effective treatment modality for chronic periodontitis, contributing to improved patient outcomes. However, future studies with larger sample sizes and longer follow-up periods are warranted to confirm and extend these findings modality