Diet-mediated immune optimization as a preventive and therapeutic adjunct for management of multiple endocrine neoplasia

Background: Multiple endocrine neoplasia (MEN) occurs throughout the body with an array of symptoms. Its management is challenging. Diet-mediated immune dysfunction may provoke their pathogenesis and clinical symptoms. Hence, diet-mediated immune optimization strategies may be useful for their management and prevention. Objective: The objective of this study was to discuss our putative diet-mediated immune dysfunction model of cancers using MEN as a classic disease paradigm. Materials and Methods: Online searches on databases such as Google Scholar, PubMed, Biomed Central, Directorate of Open Access Journal (DOAJ), and SciELO were carried out. An attempt was made to review articles with keywords such as cancer, tumor immunology, MEN, diet and immune system, T lymphocyte activation/dysfunction, and cytokines in cancers. Results: Putative diet-mediated immune dysfunction mechanisms in MEN and diet-mediated immune optimization strategies were found to be useful in preventing MEN, and as effective therapeutic adjuncts for management of MEN. Conclusion: Diet-mediated immune optimization could serve as a preventive and therapeutic adjunct for the management of MEN and other cancers.