在药物开发中采用人工智能方法:医学新时代

Omega John Unogwu, Mabel Ike, Opkanachi Omatule Joktan
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引用次数: 0

摘要

人工智能(AI)在药物开发中发挥着至关重要的作用。从目标识别和先导优化到临床试验和上市后监测,整个药物开发过程都有可能被人工智能彻底改变。数据分析是人工智能蓬勃发展的关键领域。为了找到趋势、相关性和治疗干预的前瞻性目标,人工智能系统可以分析海量数据,包括电子健康记录、分子数据库、学术文献和临床试验数据。这样,研究人员就能决定研究哪些化合物或途径,从而节省时间和资源。先导药物优化是人工智能的另一个重要领域,因为算法可以筛选和预测候选新药的疗效。为了提高疗效、安全性和药代动力学,最有前途的先导药物将被优先考虑,其属性也将得到优化。通过研究过去的数据,找出最有可能对某种药物产生反应的患者群体,人工智能还能改进临床试验设计和患者选择。这不仅提高了成功率,有助于开发个性化药物,还能在药品获得许可后,通过持续扫描真实世界的数据,发现不良事件或意外的药物相互作用,从而支持药品上市后的监控。这样就能更快地发现潜在的安全问题,有助于维护已获许可药物的持续安全性。然而,要在药物开发中完全利用人工智能,还必须克服一些障碍。这些障碍包括对高质量数据的要求、确保人工智能模型的透明度和可解释性、考虑道德问题以及在药物开发中使用人工智能的监管框架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Employing Artificial Intelligence Methods in Drug Development: A New Era in Medicine
Artificial intelligence (AI) plays a vital role in the development of pharmaceuticals. The whole drug development process, from target identification and lead optimization to clinical trials and post-marketing monitoring, has the potential to be revolutionized by AI. Data analysis is a crucial area where AI thrives. To find trends, correlations, and prospective targets for therapeutic intervention, AI systems can analyse enormous volumes of data, including electronic health records, molecular databases, academic literature, and clinical trial data. This saves time and resources by enabling researchers to decide which compounds or pathways to investigate. Lead optimization is another area where AI is essential since algorithms can screen and forecast the efficacy of new drug candidates. To improve efficacy, safety, and pharmacokinetics, the most promising leads are prioritized, and their attributes are optimized. By examining past data to pinpoint patient groupings that are most likely to respond to a certain medication, AI can also improve clinical trial design and patient selection. This advances success rates aids in the development of personalized medication and can support post-marketing surveillance by continuously scanning real-world data for adverse events or unexpected drug-drug interactions after a medicine has been licensed. This permits the quicker detection of potential safety issues and contributes to maintaining the continuous safety of licensed medications. However, some obstacles must be overcome to completely utilize AI in medication development. These include the requirement for high-quality data, assuring AI model transparency and interpretability, taking into account ethical issues, and regulatory frameworks for using AI in drug development.
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