接种流感疫苗对儿童 COVID-19 发病率和严重程度的影响

Yu. V. Ponomareva, I. N. Shisimorov, O. Magnitskaya, T. V. Plakhotnyuk, K. S. Krasnova
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摘要

新型冠状病毒感染 COVID-19 的大流行促使人们开始研究如何找到对免疫系统产生非特异性影响的方法,从而改变传染病的病程。成人研究结果表明,接种季节性流感疫苗对发病率、住院率和减少严重形式的 SARS-CoV-2 感染有积极作用。这表明在儿童中也有类似的作用。 研究目的:确定流感疫苗接种对伏尔加格勒儿童 COVID-19 发病率和严重程度的可能影响。 材料和方法对 303 名 3-17 岁无慢性病史的儿童进行了流感疫苗接种(235/303)与未接种疫苗组(68/303)对新型冠状病毒感染 COVID-19 的发病率和严重程度影响的前瞻性队列比较研究。 结果。所有新感染冠状病毒COVID-19(经实验室检测确诊--U07.1)的儿童都有轻微的疾病症状。在所有年龄组中,接种过流感疫苗的儿童与未接种过流感疫苗的儿童在新发冠状病毒感染 COVID-19 的发病率和严重程度上没有显著差异。 结论我们的研究结果不支持接种季节性流感疫苗对健康儿童 COVID-19 的发病率和严重程度具有保护作用的假设。要确定流感疫苗接种对慢性病儿童 COVID-19 严重程度的影响,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of influenza vaccination on the morbidity and severity of COVID-19 in children
The pandemic of a new coronavirus infection COVID-19 initiated research to find methods of non-specific influence on the immune system that can change the course of infectious diseases. Adult study results have been demonstrated the positive effect of seasonal influenza vaccination on morbidity, hospitalization rates, and reducing the severe forms of SARS-CoV-2 infection. That suggests a similar action in children.   The aim of the study: to establish the possible impact of influenza vaccination on the morbidity and severity of COVID-19 in children in Volgograd.   Materials and methods. The 303 children 3-17 years old without a history of chronic diseases were included in comparative prospective cohort study on the impact of influenza vaccination (235/303) on morbidity and severity of a new coronavirus infection COVID-19 vs non-vaccinated group (68/303).   Results. All children with new coronavirus infection COVID-19 (diagnosis confirmed by laboratory testing - U07.1) had mild symptoms of the disease. In all age groups, the morbidity and the severity of the new coronavirus infection COVID-19 among children vaccinated against influenza did not have significant differences with non-vaccinated group.   Conclusion. The results of our study did not support the hypothesis of a protective role of seasonal influenza vaccination on the morbidity and severity of COVID-19 in healthy children. Further research is needed to establish the effect of influenza vaccination on the severity of COVID-19 in children with chronic diseases.
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