促进人类福祉的潜在候选生物催化剂

Sahu N
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引用次数: 0

摘要

早在 6000 年前,人类就知道了酿酒,生物催化技术也因此而闻名于世。随后,来自微生物的酶被用于啤酒、葡萄酒、奶酪等工业生产中。近 100 年来,生物催化剂已被用于化学转化。为了获得具有高化学选择性、区域选择性和对映体选择性的药用和农用化学品,生物催化将微生物学家、酶学家和有机化学家结合在一起。由于生物催化剂可以避免使用有机催化剂或贵金属(与手性配体和分子氢结合使用),碳碳双键的饱和对通常的化学方法提出了挑战。过去 30 年来,它们一直被用于合成有价值的精细化学品,尤其是药品。本综述简要介绍了包括光合蓝绿藻在内的微生物生物催化剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biocatalyst Potential Candidate for Human Welfare
Biocatalysis is known since man knew about brewing which was known since 6000 years. Enzymes from microbial sources were then employed in industries such as production of beer, wine, cheese etc. Nearly 100 years down the lane biocatalysts have been used for chemical transformations. In order to access the repertoire of pharmacological and agrochemicals with high chemoselectivity, regioselectivity, and enantioselectivity, biocatalysis integrates microbiologists, enzymologists, and organic chemists. The usual chemical approach is challenged by the saturation of carbon-carbon double bonds by biocatalysts, as they avoid the usage of organocatalysts or precious metals (in combination with chiral ligands and molecular hydrogen). Since past 30 years they have been used for the synthesis of valuable fine chemicals especially pharmaceuticals. This review gives a brief about microbial biocatalyst including the photosynthetic blue-green algae.
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