桑格试剂与对苯二胺反应的预期和意外产物

IF 1 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Research Pub Date : 2023-11-01 DOI:10.1177/17475198231212673

M. Plater, William TA Harrison

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引用次数: 0

摘要

对苯二胺与桑格试剂在热乙醇中发生反应，生成预期的单取代和二取代产物，但在室温乙醇中，只生成 2-硝基-5-氟苯基-对苯二胺，其中一个氢原子被活化的未取代位置上的攻击取代。比较了对苯二胺和苯胺与桑格试剂在廉价的 "绿色 "溶剂乙醇中的反应。

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Expected and unexpected products from reacting Sanger’s reagent with p-phenylenediamine

p-Phenylenediamine reacts with Sanger’s reagent in hot ethanol to give the expected mono- and di-substitution products, but in ethanol at room temperature, it gave exclusively 2-nitro-5-fluorophenyl- p-phenylenediamine, where a hydrogen atom is displaced by attack at an activated, unsubstituted position. The reactions of p-phenylenediamine and aniline with Sanger’s reagent were compared in the cheap, ‘green’ solvent ethanol.

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来源期刊

Journal of Chemical Research CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

1.0 months

期刊介绍： The Journal of Chemical Research is a monthly journal which has a broad international authorship and publishes research papers and reviews in all branches of experimental chemistry. Established in 1977 as a joint venture by the British, French and German chemical societies it maintains the high standards set by the founding societies. Each paper is independently peer reviewed and only carefully evaluated contributions are accepted. Recent papers have described new synthetic methods, new heterocyclic compounds, new natural products, and the inorganic chemistry of metal complexes.