评估非小细胞肺癌患者同源重组系统基因 DNA 拷贝数表达和畸变的预后潜力

Cardiometry Pub Date : 2023-11-01 DOI:10.18137/cardiometry.2023.29.conf.25

M. Tsyganov, E.O. Rodionov, M. Ibragimova, S. S. Sorokovikova, A. A. Karchevskaya

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引用次数: 0

摘要

大量研究表明，乳腺肿瘤中存在的同源重组缺陷（HRD）可能是DNA损伤剂（如铂类和含蒽环类药物治疗方案）化疗效果的良好标志。然而，由于 BRCA1/2 基因紊乱而形成的 HRD 不仅是乳腺癌和卵巢癌的典型症状，也是其他癌症，尤其是非小细胞肺癌（NSCLC）的典型症状。由于对 NSCLC 患者使用铂类药物是一种标准的治疗方案，因此研究同源重组基因的表达谱以及其中是否存在染色体畸变将使我们能够对这些患者的 HRD 进行全面研究，并找出新的预后标志物。

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ASSESSMENT OF THE PROGNOSTIC POTENTIAL OF EXPRESSION AND ABERRATIONS IN THE NUMBER OF DNA COPIES OF THE HOMOLOGICAL RECOMBINATION SYSTEM GENES IN PATIENTS WITH NON-SMALL CELL LUNG CANCER

Numerous studies have shown that the presence of homologous recombination deficiency (HRD) in breast tumors may be a good marker of the effectiveness of chemotherapy with DNA-damaging agents such as platinum-based and anthracycline-containing medication regimens. However, the formation of HRD due to disruptions in the BRCA1/2 genes is typical not only for breast cancer and ovarian cancer, but also for other cancer localizations, in particular for non-small cell lung cancer (NSCLC). Since the use of platinum-based drugs in patients with NSCLC is a standard treatment protocol, studying the expression profile of homologous recombination genes and the presence of chromosomal aberrations therein will allow us to fully study HRD in these patients and identify new prognostic markers.

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来源期刊

Cardiometry MEDICAL LABORATORY TECHNOLOGY-

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Cardiometry is an open access biannual electronic journal founded in 2012. It refers to medicine, particularly to cardiology, as well as oncocardiology and allied science of biophysics and medical equipment engineering. We publish mainly high quality original articles, reports, case reports, reviews and lectures in the field of the theory of cardiovascular system functioning, principles of cardiometry, its diagnostic methods, cardiovascular system therapy from the aspect of cardiometry, system and particular approaches to maintaining health, engineering peculiarities in cardiometry developing. The interdisciplinary areas of the journal are: hemodynamics, biophysics, biochemistry, metrology. The target audience of our Journal covers healthcare providers including cardiologists and general practitioners, bioengineers, biophysics, medical equipment, especially cardiology diagnostics device, developers, educators, nurses, healthcare decision-makers, people with cardiovascular diseases, cardiology and engineering universities and schools, state and private clinics. Cardiometry is aimed to provide a wide forum for exchange of information and public discussion on above scientific issues for the mentioned experts.