Vanya Koleva, A. Dragoeva, Zheni Dimitrova, Stefani Toshkova, Mariya Rogova
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引用次数: 0
摘要
摘要 目前的研究重点是将药用植物次生代谢物作为新抗癌剂的来源。本研究旨在评估从自然生境、体外繁殖和体外培育的植物中提取的蓍草甲醇提取物对肿瘤细胞增殖/存活率的体外影响。所有测试的提取物（50 µg/ml，24 小时）都能明显抑制 SK-HEP-1 细胞株的增殖/存活率（Р ≤ 0.05）。与在自然栖息地生长的 A. thracica 相比，体外培育植物的抑制作用稍弱。因此，对 A. thracica 的异地保护为探索其宝贵的植物化学物质提供了机会。
Anticancer activity of Achillea thracica Velen. methanol extracts
Abstract Current studies are focused on medicinal plants secondary metabolites as a source of new anticancer agents. The aim of this study was to evaluate in vitro influence of methanolic extracts of Achillea thracica Velen. from natural habitat, in vitro propagated and ex vitro established plants on tumor cells proliferation/viability. All extract tested (50 µg/ml for 24 hours) significantly inhibited SK-HEP-1 cell line proliferation/viability (Р ≤ 0.05). The inhibitory effect of ex vitro established plants was slightly weaker in comparison with A. thracica grown in its natural habitat. So, ex situ conservation of A. thracica enables an opportunity to explore its valuable phytochemicals.
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