香叶醇对子宫内膜癌细胞系的化学预防作用的最新进展：基于信号通路的关键试验综述

IF 0.2 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Research Journal of Biotechnology Pub Date : 2023-11-05 DOI:10.25303/1812rjbt1420146

Shanmugapriya Sakkaravarthy, Latha Sukumaran, Kanagaraj Chinnasamy, Rashika Murugan

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引用次数: 0

摘要

本研究通过监测肿瘤发病率，分析早期反应基因、信号通路（NF-kB、CREB、环磷酸腺苷、RAS-MAPK、ERK1/2、p38、PI3K/AKT、PTEN）的状态，以及明确 I 型和 II 型子宫内膜癌变细胞（HEC-155/180、HEC-1A）DNA 甲基化改变的意义，研究了香叶醇的化学预防潜力。这些基因通过向邻近蛋白添加磷酸基团的信号级联进行交流，最终激活并转移。这表明，结合生物学知识的综合计算方法可以确定表达特征，作为多种肿瘤共同的潜在诊断生物标志物。

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Recent advances in chemopreventive effect of geraniol against endometrial cancer cell lines: A review of key trials based on signalling pathways

The present study investigated the chemopreventive potential of geraniol by monitoring the tumor incidence and analyzing the status of early response gene, signalling pathways (NF-kB, CREB, cyclic AMP, RAS-MAPK, ERK1/2, p38, PI3K/AKT, PTEN) and also clarifying the significance of DNA methylation alteration during endometrial carcinogenesis type I and type II cells (HEC-155/180, HEC-1A). These genes communicate through a signalling cascade by adding phosphate group to neighboring proteins and this will eventually activate and translocate. This shows that an integrated computational approach combined with biological knowledge could identify expression signatures as potential diagnostic biomarkers common to multiple tumors.

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来源期刊

Research Journal of Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-

CiteScore

0.60

自引率

0.00%

发文量

192

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