石菖蒲叶提取物通过调节 JNK/ASK-1 信号通路对抗扑热息痛诱导的大鼠肝毒性

IF 0.2 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Research Journal of Biotechnology Pub Date : 2023-11-05 DOI:10.25303/1812rjbt1220129

K. K. Agrawal, Y. Murti

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引用次数: 0

摘要

这项研究的目的是评估草苁蓉嫩叶的保肝功效。研究人员使用氯仿、乙酸乙酯和蒸馏水，通过冷浸渍和超音波法萃取了草决明嫩叶。研究过程中对雄性 Wistar 大鼠的体重、肝脏重量、血清生物标志物和抗氧化标志物进行了测量。在剂量为 200 毫克/千克时，提取物/馏分能明显增加大鼠肝脏的绝对和相对重量（P<0.05）。在上述剂量下，它还抑制了血清生物标志物（P<0.05）。口服提取物/馏分可明显增加氧化标志物，并降低扑热息痛诱导的肝毒性进展。研究结果表明，石菖蒲叶提取物/萃取物可以减轻扑热息痛引起的肝毒性。

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Calotropis procera leaf extract against paracetamol induced hepatotoxicity in Rats by regulating JNK/ASK-1 Signaling Pathway

The goal of the study was to assess the hepatoprotective efficacy of young Calotropis procera leaves. The young leaves of Calotropis procera were extracted by cold maceration with ultra-sonication using chloroform, ethyl acetate and distilled water. Male Wistar rats were used for hepatoprotective evaluation and the body weight, liver weight, serum biomarkers and anti-oxidant markers were measured during study. The extract/fractions significantly (P<0.05) increased the absolute and relative weight of the liver of rats at the dose of 200 mg/kg. It also suppressed the serum biomarkers (P<0.05) in the aforementioned doses. Oral administration of extract/fractions significantly increase the oxidative marker and decreased the progression of paracetamol induced hepatotoxicity. The result of the study suggested that Calotropis procera leaf extract/fractions can reduce hepatotoxicity caused by paracetamol.

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来源期刊

Research Journal of Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-

CiteScore

0.60

自引率

0.00%

发文量

192

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