Enhancement of water solubility of Poorly Water-soluble drug using milk protein as carrier

Introduction: The two key challenges for formulation scientists in developing therapeutic delivery are the dissolution and solubility of a low aqueous-soluble drug. Many powerful drug molecules do not have therapeutic effects owing to solubility concerns, yet they can be dangerous when administered in large dosages. Solid dispersion technology is a good method for increasing solubility and dissolution, along with bioavailability. Material and Methods: solid dispersion of rosuvastatin was developed using casein, infant formula, and poly-ethylene glycol 6000 by conventional fusion method and characterized for several characterization parameters. Conclusion: Solid dispersion of rosuvastatin was efficiently developed. The dissolution of rosuvastatin solid dispersion was discovered to be noticeably increased as compared to rosuvastatin API, according to the current investigation, SD of rosuvastatin was a superior alternative for increasing the dissolution of weakly soluble therapeutic agent.