DETECTION OF CLASS IgG ANTIBODIES SPECIFIC TO SOME FLAVIVIRUSES IN THE POPULATION OF THE REPUBLIC OF GUINEA

Abstract. Introduction. Genus Flavivirus (family Flaviviridae) viruses profoundly contribute to the spread of arbovirus infections. In the territory of the Republic of Guinea, the circulation of flaviviruses such as yellow fever virus (YFV), West Nile virus (WNV) and dengue fever virus (DENV) has been confirmed. The aim of the study was to determine the level of IgG antibodies specific to YFV, DENV and WNV in the indigenous population in various landscape and geographical zones of the Republic of Guinea. Materials and methods. For the study, a panel of 1559 human blood sera were compiled, which were collected in all landscape and geographical zones. The detection of IgG antibodies against DENV and WNV was carried out by commercial test systems, YFV by an experimental ELISA test system based on an analog of the third domain of protein E. Results. While testing 1559 blood serum samples, 28.48% (95% CI: 26.3-30.7) of cases were found to have IgG antibodies against YFV, DENV in 11,8%, (95% CI: 10,3-13,5) and WNV in 27% (95% CI: 24,8-29,3). simultaneously, antibodies against the three viruses (YFV, DENV and WNV) were detected in 30 cases, YFV and DENV in 14, YFV and WNV in 44, DENV and WNV in 56 cases. Conclusions. The detection of antibodies to WNV and DENV confirms the continued circulation of these pathogens in the territory of the Republic of Guinea, which poses a risk to the health of the indigenous population. The level of IgG class antibodies against YFV is insufficient for formation of yellow fever herd immunity, because. according to the WHO, it should reach at least 80% of the total indigenous population.