阿尔汉格尔斯克州医院结肠癌根治术后的存活率:基于人口的分析

Q4 Medicine
D. Bogdanov, A. V. Berezin, E. Potekhina, E. Mordovsky, M. Valkov
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引用次数: 0

摘要

背景:手术是治疗结肠癌(cc)的主要方法。本研究的目的是评估 2010-21 年在阿尔汉格尔斯克州(俄罗斯西北部)国立医院进行结肠癌根治术后的存活率。材料与方法:从阿尔汉格尔斯克州癌症登记处(ARCR)获得了所有 2142 例结肠癌根治术病例的数据。用生存率表估算了一年和五年的癌症特异性生存率;用 Kaplan-meier 法计算了累积生存函数。为确定与国立医院根治术后CC死亡风险相关的独立预测因素(包括性别、诊断时的年龄、CC的地形、形态和分期),进行了单变量和多元Cox回归分析。所有患者的一年和五年生存率分别为 86.5%(95% CI:84.9-87.9%)和 65.1%(95% CI:62.7-67.4%)。在acc接受手术的患者的5年生存率明显高于在其他州立非专科医院接受手术的患者(76.0%(95% CI:72.5-79.0%对49.3-73.8%,P<0.0001)。CC患者的相对死亡风险取决于进行根治术的州立医院和CC的分期,而与患者的性别、CC的形态和地形无关。结论:我们的研究结果表明,有必要寻找在非专科医院进行根治术后患者存活率相对较低的具体原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Colon cancer survival after radical surgery performed in hospitals of the Arkhangelsk region: a population-based analysis
Background. surgery is the main method of treatment of colon cancer (cc). Radical surgery performed in non-specialized hospitals can lead to the adverse outcomes.The aim of this study was to assess CC survival after radical surgery performed in state hospitals of the arkhangelsk region (North-West Russia) in 2010–21.Material and Methods. data on all the 2142 cases of radical surgery of CC were obtained from the arkhangelsk regional cancer registry (ARCR). One- and five-year cancer-specific survival rates were estimated by the survival tables; cumulative survival function was calculated by the Kaplan–meier method. Univariate and multiple cox regression analysis was carried out to identify independent predictors associated with CC death risk after radical surgery in state hospitals (incl. sex, age at the time of diagnosis, topography, morphology and stage of CC).Results. less than half (42.8 %) of patients underwent surgery at the arkhangelsk clinical cancer center (accc), a single specialized hospital. one- and five-year survival rates of all patients were 86.5 % (95 % CI: 84.9–87.9 %) and 65.1 % (95 % ci: 62.7–67.4 %), respectively. The 5-year survival rate of patients who underwent surgery in the accc was significantly higher than that in patients who underwent surgery in other state non-specialized hospitals (76.0 % (95 % ci: 72.5–79.0 % versus 49.3–73.8 %, p<0.0001). The relative risk of death of CC patients depended on the state hospital where radical surgery was performed and the stage of CC; it did not depend on patients’ sex, morphology and topography of CC.Conclusion. our results demonstrate the need to search for specific reasons for the relatively low survival in patients after radical surgery performed in non-specialized hospitals.
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来源期刊
Siberian journal of oncology
Siberian journal of oncology Medicine-Oncology
CiteScore
0.40
自引率
0.00%
发文量
117
审稿时长
8 weeks
期刊介绍: The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets
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