{"title":"小鼠白细胞介素-1 β的减少:IL-1 β功能成熟的可能机制。","authors":"H U Beuscher, C Günther, M Röllinghoff","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Studies related to the functional activity of human endogenous pyrogen have emphasized its susceptibility to oxidative inactivation. Here we show that the specific activity of murine IL-1 beta polypeptides can be increased by reduction and subsequent alkylation. This treatment induces a change in the relative molecular weight from 20 kDa to 21 kDa of the molecule, suggesting that conformational changes may play a critical role in the functional maturation of IL-1 beta molecules.</p>","PeriodicalId":18130,"journal":{"name":"Lymphokine research","volume":"8 3","pages":"251-5"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reduction of murine interleukin-1 beta: a possible mechanism in the functional maturation of IL-1 beta.\",\"authors\":\"H U Beuscher, C Günther, M Röllinghoff\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Studies related to the functional activity of human endogenous pyrogen have emphasized its susceptibility to oxidative inactivation. Here we show that the specific activity of murine IL-1 beta polypeptides can be increased by reduction and subsequent alkylation. This treatment induces a change in the relative molecular weight from 20 kDa to 21 kDa of the molecule, suggesting that conformational changes may play a critical role in the functional maturation of IL-1 beta molecules.</p>\",\"PeriodicalId\":18130,\"journal\":{\"name\":\"Lymphokine research\",\"volume\":\"8 3\",\"pages\":\"251-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1989-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lymphokine research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lymphokine research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Reduction of murine interleukin-1 beta: a possible mechanism in the functional maturation of IL-1 beta.
Studies related to the functional activity of human endogenous pyrogen have emphasized its susceptibility to oxidative inactivation. Here we show that the specific activity of murine IL-1 beta polypeptides can be increased by reduction and subsequent alkylation. This treatment induces a change in the relative molecular weight from 20 kDa to 21 kDa of the molecule, suggesting that conformational changes may play a critical role in the functional maturation of IL-1 beta molecules.
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